Tbio CRTC3 CREB-regulated transcription coactivator 3

Protein Summary

Description

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q6UUV7
• Q6DK61
• Q6DK62
• Q8NF38
• Q9H6U2

Gene Name

• CRTC3

Ensembl ID

• ENST00000268184
• ENSP00000268184
• ENSG00000140577
• ENST00000420329
• ENSP00000416573

Symbol

• TORC3
• TORC3
• TORC-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.81
transcription factor perturbation	0.8
cell type or tissue	0.7
transcription factor binding site profile	0.69
microRNA	0.67

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Leucine Zipper Transcription Factor / Creb-related Transcription Factor / Creb-regulated Transcription Coactivator 3

DTO Classes

Protein / Transcription Factor / Basic Leucine Zipper Transcription Factor / Creb-regulated Transcription Coactivator 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.25   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 118   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.25   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0