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Tbio
PAQR3
Progestin and adipoQ receptor family member 3

Protein Summary
Description
Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi. This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor suppressor by inhibiting the Raf/MEK/ERK signaling cascade. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395594
  • ENSP00000378959
  • ENSG00000163291
  • ENST00000511594
  • ENSP00000425080
  • ENST00000512733
  • ENSP00000421981
  • ENST00000512760
  • ENSP00000426875
  • ENST00000515853
  • ENSP00000422357

Symbol
  • RKTG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
cell type or tissue
0.72
tissue sample
0.7
biological process
0.67
microRNA
0.66


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.85   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.85   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0