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Tbio
PAQR6
Membrane progestin receptor delta

Protein Summary
Description
Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). Involved in neurosteroid inhibition of apoptosis (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23763432, PubMed:23161870).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292291
  • ENSP00000292291
  • ENSG00000160781
  • ENST00000335852
  • ENSP00000338330
  • ENST00000356983
  • ENSP00000349474
  • ENST00000368270
  • ENSP00000357253

Symbol
  • PRdelta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
gene perturbation
0.62
tissue
0.58
small molecule perturbation
0.5
PubMedID
0.48


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.93   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.93   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0