Property Summary

NCBI Gene PubMed Count 23
PubMed Score 143.94
PubTator Score 66.30

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
lung carcinoma 2844 2.10334883954989E-28
malignant mesothelioma 3163 5.46436331778418E-8
medulloblastoma, large-cell 6234 1.55705197197661E-5
osteosarcoma 7933 3.51616608583187E-5
group 3 medulloblastoma 2254 3.57504064580279E-5
psoriasis 6685 3.6031710282861E-4
Disease Target Count Z-score Confidence
Muscular atrophy 67 3.74 1.9
Osteoporosis 259 3.157 1.6
Hypogonadism 70 3.036 1.5


  Differential Expression (6)

Disease log2 FC p
malignant mesothelioma -2.700 0.000
psoriasis -1.600 0.000
osteosarcoma -1.773 0.000
medulloblastoma, large-cell 1.300 0.000
group 3 medulloblastoma 1.400 0.000
lung carcinoma 1.100 0.000


Accession Q6SZW1 O60277 Q7LGG3 Q9NXY5
Symbols SARM


  Ortholog (9)

Species Source
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
C. elegans OMA Inparanoid

Gene RIF (16)

26844829 Active nerve degeneration requires SARM1 and MAP kinases, including DLK, while the NAD+ synthetic enzyme NMNAT2 prevents degeneration.
26592460 Data show that sterile alpha- and armadillo-motif-containing protein (SARM) modulates MyD88 protein-mediated Toll-like receptors (TLRs) activation through BB-loop dependent interleukin-1 receptor (TIR) TIR-TIR interactions.
24840802 Rapid Wallerian degeneration requires the pro-degenerative molecules SARM1.
24021647 Data found that the UXT isoforms elicit dual opposing regulatory effects on SARM-induced apoptosis.
23923041 The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling.
23885119 These results indicate that association of PINK1 with SARM1 and TRAF6 is an important step for mitophagy.
23175186 SARM overexpression caused mitochondrial clustering which has also been observed in several cell death phenomenon.
22145856 The N-terminal 27 amino acids (S27) of SARM, which is hydrophobic and polybasic, acts as a mitochondria-targeting signal sequence, associating SARM to the mitochondria. The S27 peptide has an inherent ability to bind to lipids and mitochondria.
21048031 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20306472 SARM-mediated inhibition may not be exclusively directed at TRIF or MyD88, but that SARM may also directly inhibit MAPK phosphorylation
19913121 Observational study of gene-disease association. (HuGE Navigator)
18089857 SARM1 deficiencies may uncover unexpected similarities between the ways in which neurons and immune cells sense and respond to danger.
17804407 confirmed the co-localization of retinoschisin with Na/K ATPase and SARM1 in photoreceptors and bipolar cells of retina tissue
16964262 TIR adaptor SARM is a negative regulator of Toll-like receptor signaling.
15893701 Candidate gene in the onset of hereditary infectious/inflammatory diseases.

AA Sequence

GRSSRDSSAGSDTSLEGAAPMGPT                                                  701 - 724

Text Mined References (25)

PMID Year Title
26844829 2016 Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism.
26592460 2016 SARM modulates MyD88-mediated TLR activation through BB-loop dependent TIR-TIR interactions.
25080503 2014 Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels.
24840802 2014 Wallerian degeneration: an emerging axon death pathway linking injury and disease.
24021647 2013 UXT plays dual opposing roles on SARM-induced apoptosis.
23923041 2013 The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling.
23885119 2013 SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria.
23175186 2013 T-cell death following immune activation is mediated by mitochondria-localized SARM.
22145856 2012 Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence.
21048031 2011 Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20306472 2010 SARM inhibits both TRIF- and MyD88-mediated AP-1 activation.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
18089857 2007 Studies of SARM1 uncover similarities between immune and neuronal responses to danger.
17804407 2007 Retinoschisin (RS1), the protein encoded by the X-linked retinoschisis gene, is anchored to the surface of retinal photoreceptor and bipolar cells through its interactions with a Na/K ATPase-SARM1 complex.
17724133 2007 MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival.
17258210 2007 MAPPIT analysis of TLR adaptor complexes.
16985498 2006 DisSARMing Toll-like receptor signaling.
16964262 2006 The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.
15893701 2005 SARM1: A candidate gene in the onset of hereditary infectious/inflammatory diseases.
15123841 2004 Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11386760 2001 A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo/beta-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans.
9628581 1998 Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.