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Tbio Type-1 angiotensin II receptor-associated protein

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.

This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 27
PubMed Score 40.39
PubTator Score 13.27

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Hypertension 396 3.821 1.9

Expression

  Differential Expression (9)

Disease log2 FC p
adult high grade glioma 1.400 1.1e-04
Astrocytoma, Pilocytic 1.500 3.5e-08
atypical teratoid / rhabdoid tumor 1.900 7.2e-07
ependymoma 1.400 3.8e-02
glioblastoma 1.500 6.4e-09
juvenile dermatomyositis 1.144 4.9e-08
osteosarcoma -2.565 4.9e-08
tuberculosis 2.300 9.3e-10
ulcerative colitis 1.400 1.3e-06

Synonym

Accession Q6RW13 A8MVQ5 Q5SNV4 Q5SNV5 Q96AC0 Q96PL4 Q9NRW9
Symbols ATRAP

Gene

AGTRAP

  Ortholog (11)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (11)

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 GO Function (1)

 GO Component (9)

 GO Process (2)

 Compartment GO Term (42)

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 MGI Phenotype (3)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

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Pathway (4)

Gene RIF (13)

AA Sequence 

MELPAVNLKVILLGHWLLTTWGCIVFSGSYAWANFTILALGVWAVAQRDSIDAISMFLGGLLATIFLDIV      1 - 70
HISIFYPRVSLTDTGRFGVGMAILSLLLKPLSCCFVYHMYRERGGELLVHTGFLGSSQDRSAYQTIDSAE     71 - 140
APADPFAVPEGRSQDARGY                                                       141 - 159
//

Text Mined References (30)

PMID Year Title