Tbio | Type-1 angiotensin II receptor-associated protein |
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Comments
Disease | Target Count | P-value |
---|---|---|
tuberculosis | 2010 | 9.3e-10 |
glioblastoma | 5792 | 6.4e-09 |
Astrocytoma, Pilocytic | 3081 | 3.5e-08 |
juvenile dermatomyositis | 1187 | 4.9e-08 |
osteosarcoma | 7950 | 4.9e-08 |
atypical teratoid / rhabdoid tumor | 5112 | 7.2e-07 |
ulcerative colitis | 1819 | 1.3e-06 |
adult high grade glioma | 3801 | 1.1e-04 |
ependymoma | 4679 | 3.8e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Hypertension | 396 | 3.821 | 1.9 |
Disease | log2 FC | p |
---|---|---|
adult high grade glioma | 1.400 | 1.1e-04 |
Astrocytoma, Pilocytic | 1.500 | 3.5e-08 |
atypical teratoid / rhabdoid tumor | 1.900 | 7.2e-07 |
ependymoma | 1.400 | 3.8e-02 |
glioblastoma | 1.500 | 6.4e-09 |
juvenile dermatomyositis | 1.144 | 4.9e-08 |
osteosarcoma | -2.565 | 4.9e-08 |
tuberculosis | 2.300 | 9.3e-10 |
ulcerative colitis | 1.400 | 1.3e-06 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG |