| Tbio | Type-1 angiotensin II receptor-associated protein |
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| tuberculosis | 2010 | 9.3e-10 |
| glioblastoma | 5792 | 6.4e-09 |
| Astrocytoma, Pilocytic | 3081 | 3.5e-08 |
| juvenile dermatomyositis | 1187 | 4.9e-08 |
| osteosarcoma | 7950 | 4.9e-08 |
| atypical teratoid / rhabdoid tumor | 5112 | 7.2e-07 |
| ulcerative colitis | 1819 | 1.3e-06 |
| adult high grade glioma | 3801 | 1.1e-04 |
| ependymoma | 4679 | 3.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hypertension | 396 | 3.821 | 1.9 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.400 | 1.1e-04 |
| Astrocytoma, Pilocytic | 1.500 | 3.5e-08 |
| atypical teratoid / rhabdoid tumor | 1.900 | 7.2e-07 |
| ependymoma | 1.400 | 3.8e-02 |
| glioblastoma | 1.500 | 6.4e-09 |
| juvenile dermatomyositis | 1.144 | 4.9e-08 |
| osteosarcoma | -2.565 | 4.9e-08 |
| tuberculosis | 2.300 | 9.3e-10 |
| ulcerative colitis | 1.400 | 1.3e-06 |
