PAOX
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
Protein Summary
Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
- ENST00000278060
- ENSP00000278060
- ENSG00000148832
- ENST00000356306
- ENSP00000348654
- ENST00000357296
- ENSP00000349847
- ENST00000476834
- ENSP00000432737
- ENST00000480071
- ENSP00000435514
- ENST00000483211
- ENSP00000434550
- ENST00000529585
- ENSP00000432517
- PAO
- PAO
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.94 | ||
histone modification site profile | 0.7 | ||
transcription factor perturbation | 0.68 | ||
cellular component | 0.67 | ||
tissue sample | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 90.01 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 208 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 90.01 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 208 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 8
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0