Tbio LVRN Aminopeptidase Q

Protein Summary

Description

Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C.

Uniprot Accession IDs

• Q6Q4G3
• A8K6J0
• C9JGD2
• Q32MR1
• Q4G0I9
• Q4G0V2
• Q86XA3
• Q8NBZ2
• AP-Q

Gene Name

• LVRN

Ensembl ID

• ENST00000357872
• ENSP00000350541
• ENSG00000172901
• ENST00000503329
• ENSP00000427418
• ENST00000504467
• ENSP00000423604
• ENST00000512314
• ENSP00000427500
• ENST00000514509
• ENSP00000427574

Symbol

• AQPEP
• APQ
• AQPEP
• TAQPEP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.75
cell line	0.7
gene perturbation	0.68
histone modification site profile	0.67
microRNA	0.65

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Aminopeptidase Q

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Aminopeptidase Q

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.65   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 21   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.65   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0