Tbio | T-cell receptor-associated transmembrane adapter 1 |
Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.
Comments
Disease | Target Count | P-value |
---|---|---|
lung carcinoma | 2844 | 1.01452374977506E-12 |
osteosarcoma | 7933 | 7.88313753044169E-5 |
tuberculosis | 1563 | 3.51887121990811E-4 |
cutaneous lupus erythematosus | 1056 | 8.02143952554356E-4 |
primary Sjogren syndrome | 789 | 0.00441791292913189 |
interstitial cystitis | 2299 | 0.0130941129215534 |
sarcoidosis | 368 | 0.0468947042103549 |
lung cancer | 4473 | 0.0492754969719831 |
Disease | log2 FC | p |
---|---|---|
cutaneous lupus erythematosus | 3.300 | 0.001 |
osteosarcoma | -3.522 | 0.000 |
tuberculosis | -1.600 | 0.000 |
lung cancer | -1.900 | 0.049 |
sarcoidosis | 1.800 | 0.047 |
interstitial cystitis | 2.100 | 0.013 |
primary Sjogren syndrome | 2.000 | 0.004 |
lung carcinoma | -2.000 | 0.000 |
PMID | Text |
---|---|
23969027 | TRIM proteins trim the balance of homoeostasis by modulating various biological pathways through protein-protein interactions. |
23699904 | MG53/TRIM72 protein can be directly applied as a therapeutic agent to increase membrane repair capacity of many cell types. |
18817831 | TRIM acts to chaperone CTLA-4 transport to the cell surface; this function would be required to account for the phenotypic and functional properties of CD8(+) Tregs. |
PMID | Year | Title |
---|---|---|
23969027 | 2013 | TRIM proteins as trim tabs for the homoeostasis. |
23699904 | 2013 | TRIM proteins in therapeutic membrane repair of muscular dystrophy. |
18817831 | 2008 | Human leukocyte antigen class I-restricted immunosuppression by human CD8+ regulatory T cells requires CTLA-4-mediated interaction with dendritic cells. |
16160011 | 2006 | Transmembrane adaptor molecules: a new category of lymphoid-cell markers. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
12660731 | 2003 | The role of PI3K in immune cells. |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
11390434 | 2001 | The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. |
11042152 | 2000 | Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |
10723796 | 2000 | The role of membrane-associated adaptors in T cell receptor signalling. |
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