Tbio TENT2 Poly(A) RNA polymerase GLD2

Protein Summary

Description

Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs (PubMed:15070731). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs (PubMed:23200856).

Uniprot Accession IDs

• Q6PIY7
• Q86WZ2
• Q8N927
• hGLD-2

Gene Name

• TENT2

Ensembl ID

• ENST00000296783
• ENSP00000296783
• ENSG00000164329
• ENST00000423041
• ENSP00000393412
• ENST00000428308
• ENSP00000396861
• ENST00000453514
• ENSP00000397563

Symbol

• GLD2
• PAPD4
• APD4
• GLD2
• TUT2
• PAPD4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.93
microRNA	0.81
transcription factor binding site profile	0.77
cell type or tissue	0.74
histone modification site profile	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.06   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.06   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0