Tbio FIGNL1 Fidgetin-like protein 1

Protein Summary

Description

Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (PubMed:23754376). May play a role in the control of male meiosis dynamic (By similarity). This gene encodes a member of the AAA ATPase family of proteins. The encoded protein is recruited to sites of DNA damage where it plays a role in DNA double-strand break repair via homologous recombination. This protein has also been shown to localize to the centrosome and inhibit ciliogenesis, and may regulate the proliferation and differentiation of osteoblasts. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• Q6PIW4
• D3DVM6
• Q86V18
• Q8ND59
• Q9H8P1
• Q9H917

Gene Name

• FIGNL1

Ensembl ID

• ENST00000356889
• ENSP00000349356
• ENSG00000132436
• ENST00000395556
• ENSP00000378924
• ENST00000419119
• ENSP00000410811
• ENST00000433017
• ENSP00000399997
• ENST00000611938
• ENSP00000484551
• ENST00000613602
• ENSP00000481751
• ENST00000615084
• ENSP00000483543
• ENST00000617389
• ENSP00000483126

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
transcription factor perturbation	0.91
histone modification site profile	0.89
cellular component	0.84
biological process	0.76

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Fidgetin-like Protein 1

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Fidgetin-like Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.23   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.23   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0