Tdark TRMT10B tRNA methyltransferase 10 homolog B

Protein Summary

Description

S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678).

Uniprot Accession IDs

• Q6PF06
• B7Z216
• B7Z3D3
• Q05DJ4
• Q5QP83
• Q8NAG2
• Q96N36

Gene Name

• TRMT10B

Ensembl ID

• ENST00000297994
• ENSP00000297994
• ENSG00000165275
• ENST00000377753
• ENSP00000366982
• ENST00000377754
• ENSP00000366983
• ENST00000488673
• ENSP00000437395
• ENST00000537911
• ENSP00000444997

Symbol

• RG9MTD3
• RG9MTD3
• bA3J10.9

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.86
cellular component	0.75
tissue	0.59
tissue sample	0.58
microRNA	0.54

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Dna Methyltransferase / Trna Methyltransferase 10 Homolog B

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Methyltransferase / Trna Methyltransferase 10 Homolog B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.43   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 105   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.43   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0