Tdark TYW1B S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase

Protein Summary

Description

Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity). Wybutosine is a hypermodified guanosine found in phenylalanine tRNA. Wybutosine functions to stabilize codon-anticodon interactions during ribosome decoding and therefore supports the maintenance of the reading frame. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. The human genome contains two closely related genes that putatively function in wybutosine synthesis. The open reading frame of this locus is disrupted in some individuals. Thus, this locus appears to be an evolving pseudogene, but may still be functional in some members of the population. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• Q6NUM6
• A0A087WZB2
• A6NG09
• B4DFY2
• Q3KQX2

Gene Name

• TYW1B

Ensembl ID

• ENST00000620995
• ENSP00000482502
• ENSG00000277149

Symbol

• RSAFD2
• RSAFD2
• LINC00069
• NCRNA00069

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
molecular function	0.81
cellular component	0.75
trait	0.61
tissue sample	0.6

Protein Classes

PANTHER Classes

Protein / Transporter / S-adenosyl-l-methionine-dependent Trna 4-demethylwyosine Synthase

Protein / Oxidoreductase / S-adenosyl-l-methionine-dependent Trna 4-demethylwyosine Synthase

DTO Classes

Protein / Enzyme / Oxidoreductase / S-adenosyl-l-methionine-dependent Trna 4-demethylwyosine Synthase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.24   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.24   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0