Property Summary

NCBI Gene PubMed Count 8
PubMed Score 20.54
PubTator Score 12.48

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
ependymoma 2514 1.32663657501104E-23
atypical teratoid / rhabdoid tumor 4369 3.63890469815456E-20
medulloblastoma 1524 2.20918832201155E-11
medulloblastoma, large-cell 6234 1.76211822095186E-8
glioblastoma 5572 9.90361258725308E-8
primitive neuroectodermal tumor 3031 4.66797943549433E-7
pilocytic astrocytoma 3086 1.32977688430207E-6
adult high grade glioma 2148 1.55927616942049E-6
lung carcinoma 2844 0.00274134102899538
non diabetic and post-ischemic heart failure 200 0.00823135929194584
astrocytic glioma 2241 0.00918644163744596
oligodendroglioma 2849 0.0396960792136976


  Differential Expression (12)

Disease log2 FC p
astrocytic glioma -2.200 0.009
ependymoma -4.300 0.000
oligodendroglioma -1.700 0.040
glioblastoma -5.000 0.000
medulloblastoma -4.800 0.000
non diabetic and post-ischemic heart fai... 1.100 0.008
atypical teratoid / rhabdoid tumor -5.400 0.000
medulloblastoma, large-cell -5.600 0.000
primitive neuroectodermal tumor -4.200 0.000
adult high grade glioma -4.300 0.000
pilocytic astrocytoma -3.000 0.000
lung carcinoma 1.100 0.003


Accession Q6MZT1 B7Z3X1
Symbols R7BP


  Ortholog (8)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

Gene RIF (5)

26895961 R7-binding protein had a strong inhibitory effect on homo-oligomerization of RGS7.
21457877 BL3-ht2 of RGS7BP may be an important genetic variant associated with AERD. The haplotype of block 3 may play a protective role against aspirin hypersensitivity in asthma, perhaps by altering the responsiveness of muscarinic receptors.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19497306 the successful purification of functionally intact Gbeta5-free recombinant RGS11 was reported that differentially interact with R7BP and Galpha(oa).
16867977 cytoplasmic RGS7*Gbeta5*R7BP heterotrimers and RGS7*Gbeta5 heterodimers are equivalently inefficient regulators of G protein-coupled receptor signaling relative to plasma membrane-bound heterotrimers bearing palmitoylated R7BP.

AA Sequence


Text Mined References (12)

PMID Year Title
26895961 2016 Regulator of G Protein Signaling 7 (RGS7) Can Exist in a Homo-oligomeric Form That Is Regulated by G?o and R7-binding Protein.
21457877 2011 Association analysis of RGS7BP gene polymorphisms with aspirin intolerance in asthmatic patients.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19497306 2009 RGS11 interacts preferentially with R7BP over Galpha(oa)--characterization of Gbeta5-free RGS11.
19042037 2009 R9AP and R7BP: traffic cops for the RGS7 family in phototransduction and neuronal GPCR signaling.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
16867977 2006 R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism.
15632198 2005 R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15372022 2004 The DNA sequence and comparative analysis of human chromosome 5.