Tbio LIN54 Protein lin-54 homolog

Protein Summary

Description

Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context (PubMed:17671431, PubMed:17531812). In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes (PubMed:17671431, PubMed:17531812). In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation (PubMed:17671431, PubMed:17531812). In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner (PubMed:19725879). Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA (PubMed:27465258). LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes (Schmit et al., 2009 [PubMed 19725879]).[supplied by OMIM, Dec 2010]

Uniprot Accession IDs

• Q6MZP7
• Q32M68
• Q32M69
• Q6N071
• Q76B60

Gene Name

• LIN54

Ensembl ID

• ENST00000340417
• ENSP00000341947
• ENSG00000189308
• ENST00000442461
• ENSP00000398265
• ENST00000446851
• ENSP00000407139
• ENST00000505397
• ENSP00000425844
• ENST00000506560
• ENSP00000423475
• ENST00000508171
• ENSP00000427413
• ENST00000510557
• ENSP00000421045

Symbol

• CXCDC1
• KIAA2037
• TCX1
• JC8.6
• CXCDC1
• MIP120

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.77
microRNA	0.7
transcription factor binding site profile	0.66
tissue sample	0.65
tissue	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.4   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 54   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.4   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0