Tbio SLC25A25 Calcium-binding mitochondrial carrier protein SCaMC-2

Protein Summary

Description

Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria. The protein encoded by this gene belongs to the family of calcium-binding mitochondrial carriers, with a characteristic mitochondrial carrier domain at the C-terminus. These proteins are found in the inner membranes of mitochondria, and function as transport proteins. They shuttle metabolites, nucleotides and cofactors through the mitochondrial membrane and thereby connect and/or regulate cytoplasm and matrix functions. This protein may function as an ATP-Mg/Pi carrier that mediates the transport of Mg-ATP in exchange for phosphate, and likely responsible for the net uptake or efflux of adenine nucleotides into or from the mitochondria. Alternatively spliced transcript variants encoding different isoforms with a common C-terminus but variable N-termini have been described for this gene. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q6KCM7
• Q5SYW7
• Q5SYW8
• Q5SYX3
• Q5VWU2
• Q5VWU3
• Q5VWU4
• Q6KCM4
• Q6KCM6
• Q6UX48
• Q705K2
• Q96PZ1
• Q9BSA6

Gene Name

• SLC25A25

Ensembl ID

• ENST00000373064
• ENSP00000362155
• ENSG00000148339
• ENST00000373066
• ENSP00000362157
• ENST00000373068
• ENSP00000362159
• ENST00000373069
• ENSP00000362160
• ENST00000432073
• ENSP00000410053

Symbol

• APC3
• KIAA1896
• MCSC3
• SCAMC2
• MCSC
• PCSCL
• SCAMC-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
transcription factor	0.89
protein domain	0.85
transcription factor binding site profile	0.79
tissue sample	0.67

Protein Classes

PANTHER Classes

Protein / Transporter / Mitochondrial Carrier Protein / Calcium-binding Mitochondrial Carrier Protein Scamc-2

Protein / Transporter / Amino Acid Transporter / Calcium-binding Mitochondrial Carrier Protein Scamc-2

Protein / Transfer/carrier Protein / Calcium-binding Mitochondrial Carrier Protein Scamc-2

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Calcium-binding Mitochondrial Carrier Protein Scamc-2

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc25 Family Of Mitochondrial Transporters / Mitochondrial Nucleotide Transporter Subfamily / Calcium-binding Mitochondrial Carrier Protein Scamc-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.49   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 136   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.49   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0