Tbio STYK1 Tyrosine-protein kinase STYK1

Protein Summary

Description

Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity). Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q6J9G0
• B2R9T2
• Q52LR3
• Q9BXY2
• Q9NSH1

Gene Name

• STYK1

Ensembl ID

• ENST00000075503
• ENSP00000075503
• ENSG00000060140

Symbol

• NOK
• NOK
• SuRTK106

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.97
molecular function	0.94
trait	0.75
cell type or tissue	0.63
histone modification site profile	0.6

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Tk-unique Family / Tyrosine-protein Kinase Styk1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.46   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 297   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.46   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0