Tchem NAPEPLD N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D

Protein Summary

Description

Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid (PubMed:25684574, PubMed:14634025, PubMed:16527816). Responsible for the generation of these bioactive fatty acid ethanolamides (FAEs), including anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (PubMed:14634025). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose (By similarity). NAPEPLD is a phospholipase D type enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE) in the second step of the biosynthesis of N-acylethanolamine (Okamoto et al., 2004 [PubMed 14634025]).[supplied by OMIM, Oct 2008]

Uniprot Accession IDs

• Q6IQ20
• Q5CZ87
• Q769K1
• N-acyl phosphatidylethanolamine phospholipase D

Gene Name

• NAPEPLD

Ensembl ID

• ENST00000341533
• ENSP00000340093
• ENSG00000161048
• ENST00000417955
• ENSP00000407112
• ENST00000422589
• ENSP00000412376
• ENST00000427257
• ENSP00000392775
• ENST00000465647
• ENSP00000419188
• ENST00000611100
• ENSP00000482162
• ENSG00000275723
• ENST00000622712
• ENSP00000481285
• ENST00000632159
• ENSP00000488504
• ENST00000632703
• ENSP00000488648
• ENST00000633783
• ENSP00000487770

Symbol

• C7orf18
• FMP30
• C7orf18
• NAPE-PLD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.92
histone modification site profile	0.78
metabolite	0.78
microRNA	0.74
kinase perturbation	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.69   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 148   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.69   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 36

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0