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Tbio
CCSAP
Centriole, cilia and spindle-associated protein

Protein Summary
Description
Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (PubMed:26562023). May play a role in embryonic development. May be required for proper cilia beating (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284617
  • ENSP00000284617
  • ENSG00000154429
  • ENST00000366686
  • ENSP00000355647
  • ENST00000366687
  • ENSP00000355648

Symbol
  • C1orf96
  • CSAP
  • CSAP
  • C1orf96
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.81
microRNA
0.79
tissue sample
0.74
transcription factor perturbation
0.74
histone modification site profile
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.75   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.75   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0