| Tdark | Desumoylating isopeptidase 1 |
Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46 (By similarity).
Comments
| Disease | Target Count | P-value |
|---|---|---|
| posterior fossa group A ependymoma | 468 | 1.8e-09 |
| lung adenocarcinoma | 2716 | 2.3e-09 |
| pediatric high grade glioma | 1064 | 9.6e-07 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.0e-06 |
| glioblastoma | 5792 | 1.4e-05 |
| osteosarcoma | 7950 | 3.0e-05 |
| group 3 medulloblastoma | 4104 | 7.0e-05 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 1.5e-03 |
| psoriasis | 6694 | 4.4e-03 |
| cutaneous lupus erythematosus | 1057 | 1.5e-02 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | -1.400 | 2.0e-06 |
| cutaneous lupus erythematosus | 1.100 | 1.5e-02 |
| glioblastoma | -1.200 | 1.4e-05 |
| group 3 medulloblastoma | -1.100 | 7.0e-05 |
| lung adenocarcinoma | 1.500 | 2.3e-09 |
| osteosarcoma | -1.314 | 3.0e-05 |
| pancreatic ductal adenocarcinoma liver m... | -1.544 | 1.5e-03 |
| pediatric high grade glioma | -1.100 | 9.6e-07 |
| posterior fossa group A ependymoma | -1.100 | 1.8e-09 |
| psoriasis | 1.300 | 4.4e-03 |
