Tdark | Desumoylating isopeptidase 1 |
Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46 (By similarity).
Comments
Disease | Target Count | P-value |
---|---|---|
medulloblastoma | 1524 | 1.32487255785935E-9 |
posterior fossa group A ependymoma | 1511 | 1.7798457079263E-9 |
lung adenocarcinoma | 2714 | 2.26721631891424E-9 |
atypical teratoid/rhabdoid tumor | 1095 | 4.04122103375423E-9 |
pediatric high grade glioma | 2712 | 9.61269329256865E-7 |
glioblastoma | 5572 | 1.42096046239755E-5 |
osteosarcoma | 7933 | 3.03635435634109E-5 |
psoriasis | 6685 | 1.35081179083501E-4 |
pancreatic ductal adenocarcinoma liver metastasis | 1795 | 0.00147562432363213 |
cutaneous lupus erythematosus | 1056 | 0.0145362834979269 |
Disease | log2 FC | p |
---|---|---|
cutaneous lupus erythematosus | 1.100 | 0.015 |
psoriasis | -1.500 | 0.000 |
osteosarcoma | -1.314 | 0.000 |
medulloblastoma | -1.400 | 0.000 |
atypical teratoid/rhabdoid tumor | -1.500 | 0.000 |
glioblastoma | -1.200 | 0.000 |
pancreatic ductal adenocarcinoma liver m... | -1.544 | 0.001 |
pediatric high grade glioma | -1.100 | 0.000 |
posterior fossa group A ependymoma | -1.100 | 0.000 |
lung adenocarcinoma | 1.500 | 0.000 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG |
Opossum | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG |
Chicken | OMA EggNOG |
Anole lizard | OMA EggNOG Inparanoid |
Xenopus | OMA EggNOG |
Zebrafish | OMA EggNOG Inparanoid |
PMID | Year | Title |
---|---|---|
22370726 | 2012 | DeSUMOylating isopeptidase: a second class of SUMO protease. |
21269460 | 2011 | Initial characterization of the human central proteome. |
20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. |
19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. |
18669648 | 2008 | A quantitative atlas of mitotic phosphorylation. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
15461802 | 2004 | A genome annotation-driven approach to cloning the human ORFeome. |
14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
10591208 | 1999 | The DNA sequence of human chromosome 22. |
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