Tdark ISM2 Isthmin-2

Protein Summary

Description

The protein encoded by this gene contains a type 1 thrombospondin domain, which is present in thrombospondin, a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q6H9L7
• A8K6D5
• O95432
• Q495U5
• Q68CN3
• Q86TQ7
• Q86TW3
• Q86TW4
• Q8N501
• Q8NBL0

Gene Name

• ISM2

Ensembl ID

• ENST00000216481
• ENSP00000216481
• ENSG00000100593
• ENST00000342219
• ENSP00000341490
• ENST00000493585
• ENSP00000420452

Symbol

• TAIL1
• THSD3
• TAIL1
• THSD3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.67
cell line	0.46
cell type or tissue	0.45
microRNA	0.43
protein complex	0.4

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.97   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 35   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.97   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0