Property Summary

NCBI Gene PubMed Count 55
PubMed Score 69.48
PubTator Score 72.79

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
psoriasis 6685 8.75851761508327E-64
lung carcinoma 2844 3.88256207310221E-22
juvenile dermatomyositis 1189 7.00184368484119E-22
malignant mesothelioma 3163 2.13980220273435E-9
non-small cell lung cancer 2798 6.84406288590275E-7
ulcerative colitis 2087 1.05550779459403E-6
cutaneous lupus erythematosus 1056 1.05439194542642E-5
lung cancer 4473 2.50615123607012E-5
pancreatic cancer 2300 1.19980032834244E-4
medulloblastoma, large-cell 6234 1.7899833516002E-4
pituitary cancer 1972 2.26048944195233E-4
tuberculosis 1563 2.56792268930329E-4
primary Sjogren syndrome 789 2.57554327601538E-4
osteosarcoma 7933 5.08909579402848E-4
group 4 medulloblastoma 1875 9.81759012432633E-4
nasopharyngeal carcinoma 1056 0.00104418030608697
ovarian cancer 8492 0.00112214199113712
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00122480330938818
Atopic dermatitis 944 0.0013913316678371
interstitial cystitis 2299 0.00142568526947822
systemic lupus erythematosus 172 0.00171237176286953
active Crohn's disease 918 0.00187608248704862
cystic fibrosis 1670 0.00480191708054028
pancreatic ductal adenocarcinoma liver metastasis 1795 0.00556764750401925
dermatomyositis 967 0.0148621889679034
Multiple Sclerosis 498 0.0169548294769807
hepatocellular carcinoma 550 0.0191231597047847
sarcoidosis 368 0.0229541107587244
invasive ductal carcinoma 2950 0.0333151080410856
subependymal giant cell astrocytoma 2287 0.036066121085123
inflammatory breast cancer 404 0.0366068133108184
Disease Target Count Z-score Confidence
Cancer 2346 3.726 1.9
Disease Target Count Z-score Confidence
Thymic dysplasia 2 3.425 1.7



Accession Q6GPH4 A2T931 A2T932 A8K2L1 A8K9Y3 D3DTM6 Q6MZE8 Q8N557 Q99982
Symbols BIRC4BP




  Ortholog (8)

Gene RIF (52)

26116899 HIV-1 Vpr upregulates the gene expression of XAF1 in human monocyte-derived dendritic cells
25824780 Underexpression of XAF1 confers cisplatin-resistance in ovarian carcinoma.
25539606 Restored XAF1 expression inhibits cell proliferation and induces cell apoptosis in human lung adenocarcinoma cell line A549. Furthermore, XAF1 may activate associated apoptotic signaling pathways in A549 cell line.
25367849 Up-regulation of XAF1 distinctly increased apoptosis in colorectal cancer cells administered cisplatin.
25313037 XAF1 stimulates HIPK2-mediated Ser-46 phosphorylation of p53 and XAF1 also steps up the termination of p53-mediated cell-cycle arrest by activating ZNF313.
25216542 Our study identified a novel splice variant of XAF1 in cancer cells
24663488 XAF1 as a possible sarcoidosis risk gene
24249729 Transcriptionally active p73 induces translocation of XAF-1 during apoptosis caused by melphalan. XAF-1 directly interacts with Puma and promotes Bax translocation during melphalan-induced apoptosis.
23645777 Missense polymorphisms in XIAP-associated factor-1 is associated with papillary thyroid cancer.
23333304 HIV-1 Vpr upregulates the gene expression of XAF1 in human monocyte-derived dendritic cells

AA Sequence

QHQEKCRWLASSKGKQVRNFS                                                     281 - 301

Text Mined References (60)

PMID Year Title
25824780 2015 XIAP associated factor 1 (XAF1) represses expression of X-linked inhibitor of apoptosis protein (XIAP) and regulates invasion, cell cycle, apoptosis, and cisplatin sensitivity of ovarian carcinoma cells.
25539606 2014 [XAF1 inhibits cell proliferation and induces apoptosis in human lung adenocarcinoma cell line A549 in vitro].
25367849 2014 X-linked inhibitor of apoptosis-associated factor l (XAFl) enhances the sensitivity of colorectal cancer cells to cisplatin.
25313037 2014 XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313.
25216542 2015 A novel splice variant of XIAP-associated factor 1 (XAF1) is expressed in peripheral blood containing gastric cancer-derived circulating tumor cells.
24663488 2014 Admixture fine-mapping in African Americans implicates XAF1 as a possible sarcoidosis risk gene.
24249729 2013 Melphalan-induced apoptosis of EBV-transformed B cells through upregulation of TAp73 and XAF1 and nuclear import of XPA.
23645777 2013 Missense polymorphisms in XIAP-associated factor-1 (XAF1) and risk of papillary thyroid cancer: correlation with clinicopathological features.
23645206 2013 ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.).
23207547 2013 XAF1 contributes to dengue virus-induced apoptosis in vascular endothelial cells.