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Tbio
ZFAND6
AN1-type zinc finger protein 6

Protein Summary
Description
Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261749
  • ENSP00000261749
  • ENSG00000086666
  • ENST00000558087
  • ENSP00000453888
  • ENST00000558494
  • ENSP00000454137
  • ENST00000559157
  • ENSP00000454152
  • ENST00000559775
  • ENSP00000453709
  • ENST00000559835
  • ENSP00000453291
  • ENST00000561060
  • ENSP00000452735
  • ENST00000613266
  • ENSP00000479071
  • ENST00000616533
  • ENSP00000478129
  • ENST00000618205
  • ENSP00000484971

Symbol
  • AWP1
  • ZA20D3
  • AWP1
  • ZA20D3
  • ZFAND5B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
kinase perturbation
0.84
cell type or tissue
0.8
transcription factor binding site profile
0.77
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.02   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.02   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0