Tbio CLEC6A C-type lectin domain family 6 member A

Protein Summary

Description

Binds high-mannose carbohydrates in a Ca(2+)-dependent manner (PubMed:28652405). Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway (By similarity). The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q6EIG7
• A2RUK3

Gene Name

• CLEC6A

Ensembl ID

• ENST00000382073
• ENSP00000371505
• ENSG00000205846

Symbol

• CLECSF10
• DECTIN2
• CLEC4N
• CLECSF10
• dectin-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.9
microRNA	0.77
cell line	0.61
transcription factor perturbation	0.61
cell type or tissue	0.54

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / C-type Lectin Domain Family 6 Member A

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / C-type Lectin Domain Family 6 Member A

Protein / Cell Adhesion Molecule / C-type Lectin Domain Family 6 Member A

DTO Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / C-type Lectin Domain Family 6 Member A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.62   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 398   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.62   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 398   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0