Tchem GPR139 Probable G-protein coupled receptor 139

Protein Summary

Description

Orphan receptor. Seems to act through a G(q/11)-mediated pathway. This gene encodes a member of the rhodopsin family of G-protein-coupled receptors. The encoded protein is almost exclusively expressed in the central nervous system. L-tryptophan and L-phenylalanine may act as the physiologic ligands of the encoded protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• Q6DWJ6
• A8K5R9
• Q86SP2
• Q8TDU8

Gene Name

• GPR139

Ensembl ID

• ENST00000570682
• ENSP00000458791
• ENSG00000180269

Symbol

• GPRG1
• PGR3
• PGR3
• GPRg1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.61
cell line	0.59
molecular function	0.49
PubMedID	0.49
phenotype	0.37

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Probable G-protein Coupled Receptor 139

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.34   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 137   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.34   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 249

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0