Tbio FCRL6 Fc receptor-like protein 6

Protein Summary

Description

Acts as a MHC class II receptor (PubMed:20519654). When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells (PubMed:17213291, PubMed:18991291). Does not act as an Fc receptor (PubMed:18991291).

Uniprot Accession IDs

• Q6DN72
• A1KXW6
• A2A4D6
• Q6DN73
• Q6XRC3
• Q6ZNI1
• FcR-like protein 6

Gene Name

• FCRL6

Ensembl ID

• ENST00000321935
• ENSP00000320625
• ENSG00000181036
• ENST00000339348
• ENSP00000340949
• ENST00000368106
• ENSP00000357086
• ENST00000392235
• ENSP00000376068

Symbol

• FCRH6
• FcRH6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.73
tissue sample	0.61
protein domain	0.58
cellular component	0.45
tissue	0.39

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Fc Receptor-like Protein 6

DTO Classes

Protein / Cell Adhesion / Fc Receptor-like Protein 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.3   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 82   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.3   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0