Tbio FCRLB Fc receptor-like B

Protein Summary

Description

FCRL2 belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin (Ig) constant regions (Chikaev et al., 2005 [PubMed 15676285]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q6BAA4
• A2A3J5
• A2A3J7
• Q5VXA6
• Q6BAA0
• Q6BAA1
• Q6BAA2
• Q6BAA3
• Q8IXZ7

Gene Name

• FCRLB

Ensembl ID

• ENST00000336830
• ENSP00000338598
• ENSG00000162746
• ENST00000367944
• ENSP00000356921
• ENST00000367945
• ENSP00000356922
• ENST00000367946
• ENSP00000356923
• ENST00000367948
• ENSP00000356925

Symbol

• FCRL2
• FCRLM2
• FCRY
• FREB2
• FcRY
• FCRL2
• FCRLY
• FREB2
• FCRLM2
• FREB-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.62
tissue sample	0.56
tissue	0.54
chemical	0.41
protein domain	0.41

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Fc Receptor-like B

DTO Classes

Protein / Cell Adhesion / Fc Receptor-like B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.41   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 116   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.41   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0