| Tbio | Cell division cycle-associated protein 2 |
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.
This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in cancer progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in cancer progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 1.5e-22 |
| psoriasis | 6694 | 8.7e-13 |
| atypical teratoid / rhabdoid tumor | 5112 | 5.8e-09 |
| glioblastoma | 5792 | 1.2e-07 |
| lung adenocarcinoma | 2716 | 1.3e-07 |
| ovarian cancer | 8520 | 1.8e-07 |
| medulloblastoma, large-cell | 6241 | 4.8e-07 |
| Breast cancer | 3578 | 1.3e-06 |
| posterior fossa group A ependymoma | 468 | 2.2e-06 |
| group 3 medulloblastoma | 4104 | 2.6e-05 |
| adult high grade glioma | 3801 | 4.5e-05 |
| primitive neuroectodermal tumor | 3035 | 1.1e-04 |
| nasopharyngeal carcinoma | 1058 | 1.4e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 2.3e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 3.1e-04 |
| ulcerative colitis | 1819 | 4.3e-04 |
| breast carcinoma | 1638 | 7.1e-04 |
| Atopic dermatitis | 952 | 1.5e-03 |
| invasive ductal carcinoma | 2951 | 2.8e-03 |
| adrenocortical carcinoma | 1428 | 7.2e-03 |
| osteosarcoma | 7950 | 2.0e-02 |
| Endometriosis | 540 | 3.7e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Dermatophytosis | 11 | 3.064 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | 1.405 | 7.2e-03 |
| adult high grade glioma | 1.600 | 4.5e-05 |
| Atopic dermatitis | 1.400 | 1.5e-03 |
| atypical teratoid / rhabdoid tumor | 2.400 | 5.8e-09 |
| Breast cancer | 1.300 | 1.3e-06 |
| breast carcinoma | 1.100 | 7.1e-04 |
| Endometriosis | 1.186 | 3.7e-02 |
| glioblastoma | 2.000 | 1.2e-07 |
| group 3 medulloblastoma | 2.500 | 2.6e-05 |
| intraductal papillary-mucinous carcinoma... | 1.700 | 2.3e-04 |
| intraductal papillary-mucinous neoplasm ... | 1.900 | 3.1e-04 |
| invasive ductal carcinoma | 1.300 | 2.8e-03 |
| lung adenocarcinoma | 2.000 | 1.3e-07 |
| medulloblastoma, large-cell | 3.000 | 4.8e-07 |
| nasopharyngeal carcinoma | 1.200 | 1.4e-04 |
| non-small cell lung cancer | 1.848 | 1.5e-22 |
| osteosarcoma | 1.514 | 2.0e-02 |
| ovarian cancer | 1.900 | 1.8e-07 |
| posterior fossa group A ependymoma | 1.300 | 2.2e-06 |
| primitive neuroectodermal tumor | 2.500 | 1.1e-04 |
| psoriasis | 1.300 | 8.7e-13 |
| ulcerative colitis | 1.200 | 4.3e-04 |
MDANSKDKPPETKESAMNNAGNASFILGTGKIVTPQKHAELPPNPCTPDTFKSPLNFSTVTVEQLGITPE 1 - 70 SFVRNSAGKSSSYLKKCRRRSAVGARGSPETNHLIRFIARQQNIKNARKSPLAQDSPSQGSPALYRNVNT 71 - 140 LRERISAFQSAFHSIKENEKMTGCLEFSEAGKESEMTDLTRKEGLSACQQSGFPAVLSSKRRRISYQRDS 141 - 210 DENLTDAEGKVIGLQIFNIDTDRACAVETSVDLSEISSKLGSTQSGFLVEESLPLSELTETSNALKVADC 211 - 280 VVGKGSSDAVSPDTFTAEVSSDAVPDVRSPATPACRRDLPTPKTFVLRSVLKKPSVKMCLESLQEHCNNL 281 - 350 YDDDGTHPSLISNLPNCCKEKEAEDEENFEAPAFLNMRKRKRVTFGEDLSPEVFDESLPANTPLRKGGTP 351 - 420 VCKKDFSGLSSLLLEQSPVPEPLPQPDFDDKGENLENIEPLQVSFAVLSSPNKSSISETLSGTDTFSSSN 421 - 490 NHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEVQPCKEKKINRRKSQETKCTKRALPKKSQVLK 491 - 560 SCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVPEMTPSIPSIRRLGSGYFSSNGKLEEVKTPK 561 - 630 NPVKRKDLLRHDPDLHMHQGYDKYDVSEFCSYIKSSSSLGNATSDEDPNTNIMNINENKNIPKAKNKSES 631 - 700 ENEPKAGTDSPVSCASVTEERVASDSPKPALTLQQGQEFSAGGQNAENLCQFFKISPDLNIKCERKDDFL 701 - 770 GAAEGKLQCNRLMPNSQKDCHCLGDVLIENTKESKSQSEDLGRKPMESSSVVSCRDRKDRRRSMCYSDGR 771 - 840 SLHLEKNGNHTPSSSVGSSVEISLENSELFKDLSDAIEQTFQRRNSETKVRRSTRLQKDLENEGLVWISL 841 - 910 PLPSTSQKAKRRTICTFDSSGFESMSPIKETVSSRQKPQMAPPVSDPENSQGPAAGSSDEPGKRRKSFCI 911 - 980 STLANTKATSQFKGYRRRSSLNGKGESSLTALERIEHNGERKQ 981 - 1023 //
