| Tbio | Cell division cycle-associated protein 2 |
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.
This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in cancer progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in cancer progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Comments
| Disease | Target Count |
|---|---|
| Peripheral Neuropathy | 303 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Dermatophytosis | 12 | 3.184 | 1.6 |
| Folliculitis | 5 | 3.104 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| osteosarcoma | 1.514 | 0.020 |
| glioblastoma | 2.500 | 0.000 |
| group 3 medulloblastoma | 2.500 | 0.000 |
| atypical teratoid / rhabdoid tumor | 2.400 | 0.000 |
| medulloblastoma, large-cell | 3.000 | 0.000 |
| primitive neuroectodermal tumor | 2.500 | 0.000 |
| Atopic dermatitis | 1.400 | 0.002 |
| adrenocortical carcinoma | 1.405 | 0.007 |
| non-small cell lung cancer | 1.848 | 0.000 |
| intraductal papillary-mucinous carcinoma... | 1.700 | 0.000 |
| intraductal papillary-mucinous neoplasm ... | 1.900 | 0.000 |
| breast carcinoma | 1.100 | 0.001 |
| pediatric high grade glioma | 2.100 | 0.000 |
| posterior fossa group A ependymoma | 1.300 | 0.000 |
| lung adenocarcinoma | 2.000 | 0.000 |
| nasopharyngeal carcinoma | 1.200 | 0.000 |
| psoriasis | 1.800 | 0.000 |
| Endometriosis | 1.186 | 0.037 |
| inflammatory breast cancer | 1.800 | 0.005 |
| invasive ductal carcinoma | 1.300 | 0.003 |
| ulcerative colitis | 1.200 | 0.000 |
| ovarian cancer | 1.900 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Pig | OMA EggNOG |
| Opossum | EggNOG Inparanoid |
| Xenopus | OMA EggNOG |
| PMID | Text |
|---|---|
| 23746640 | Aurora B phosphorylates Repo-Man at S893, preventing its recruitment by histones. |
| 23418564 | Data indicate that CDCA2 frequently is overexpressed in oral squamous cell carcinoma (OSCC) and might be associated with OSCC progression by preventing cell-cycle arrest and apoptosis. |
| 23362328 | Proteomic identification of a large number of novel RepoMan interactors. |
| 22801782 | It was shown that Repo-Man and Sds22 contribute to timely Aurora B kinase substrate dephosphorylation on anaphase chromatin. |
| 21820363 | This study demonistrated that identify Repo-Man as a key factor that coordinates chromatin remodeling and early events of nuclear envelope reformation during mitotic exit. |
| 21514157 | Repo-Man promotes H3T11ph dephosphorylation by an indirect mechanism but directly and specifically targets H3T3ph for dephosphorylation by associated PP1gamma. |
| 20379614 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 20188555 | This study reports essential DNA damage response regulation mediated by Repo-Man-protein phosphatase 1 and further delineate underlying mechanisms. |
| 16492807 | Repo-Man forms an essential complex with protein phosphatase 1 (PP1) gamma and is required for the recruitment of PP1 to chromatin |
MDANSKDKPPETKESAMNNAGNASFILGTGKIVTPQKHAELPPNPCTPDTFKSPLNFSTVTVEQLGITPE 1 - 70 SFVRNSAGKSSSYLKKCRRRSAVGARGSPETNHLIRFIARQQNIKNARKSPLAQDSPSQGSPALYRNVNT 71 - 140 LRERISAFQSAFHSIKENEKMTGCLEFSEAGKESEMTDLTRKEGLSACQQSGFPAVLSSKRRRISYQRDS 141 - 210 DENLTDAEGKVIGLQIFNIDTDRACAVETSVDLSEISSKLGSTQSGFLVEESLPLSELTETSNALKVADC 211 - 280 VVGKGSSDAVSPDTFTAEVSSDAVPDVRSPATPACRRDLPTPKTFVLRSVLKKPSVKMCLESLQEHCNNL 281 - 350 YDDDGTHPSLISNLPNCCKEKEAEDEENFEAPAFLNMRKRKRVTFGEDLSPEVFDESLPANTPLRKGGTP 351 - 420 VCKKDFSGLSSLLLEQSPVPEPLPQPDFDDKGENLENIEPLQVSFAVLSSPNKSSISETLSGTDTFSSSN 421 - 490 NHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEVQPCKEKKINRRKSQETKCTKRALPKKSQVLK 491 - 560 SCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVPEMTPSIPSIRRLGSGYFSSNGKLEEVKTPK 561 - 630 NPVKRKDLLRHDPDLHMHQGYDKYDVSEFCSYIKSSSSLGNATSDEDPNTNIMNINENKNIPKAKNKSES 631 - 700 ENEPKAGTDSPVSCASVTEERVASDSPKPALTLQQGQEFSAGGQNAENLCQFFKISPDLNIKCERKDDFL 701 - 770 GAAEGKLQCNRLMPNSQKDCHCLGDVLIENTKESKSQSEDLGRKPMESSSVVSCRDRKDRRRSMCYSDGR 771 - 840 SLHLEKNGNHTPSSSVGSSVEISLENSELFKDLSDAIEQTFQRRNSETKVRRSTRLQKDLENEGLVWISL 841 - 910 PLPSTSQKAKRRTICTFDSSGFESMSPIKETVSSRQKPQMAPPVSDPENSQGPAAGSSDEPGKRRKSFCI 911 - 980 STLANTKATSQFKGYRRRSSLNGKGESSLTALERIEHNGERKQ 981 - 1023 //
| PMID | Year | Title |
|---|---|---|
| 24563358 | 2014 | Repo-man at the intersection of chromatin remodelling, DNA repair, nuclear envelope organization, and cancer progression. |
| 23746640 | 2013 | Aurora B defines its own chromosomal targeting by opposing the recruitment of the phosphatase scaffold Repo-Man. |
| 23418564 | 2013 | Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis. |
| 23362328 | 2013 | Quantitative fragmentome mapping reveals novel, domain-specific partners for the modular protein RepoMan (recruits PP1 onto mitotic chromatin at anaphase). |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 22801782 | 2012 | Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores. |
| 22555598 | 2012 | Repo-Man-PP1: a link between chromatin remodelling and nuclear envelope reassembly. |
| 21820363 | 2011 | Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit. |
| 21514157 | 2011 | PP1/Repo-man dephosphorylates mitotic histone H3 at T3 and regulates chromosomal aurora B targeting. |
| 21406692 | 2011 | System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. |
| More... |
