Tbio INTS3 Integrator complex subunit 3

Protein Summary

Description

Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites. The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016]

Uniprot Accession IDs

• Q68E01
• A8K1W0
• B4DQC8
• B4E3U9
• D3DV57
• Q4G0E5
• Q5VUQ5
• Q5VUQ6
• Q5VUR0
• Q5VUR1
• Q68DJ1
• Q69YR5
• Q6AI57
• Q6DKG7
• Q6MZQ4
• Q6MZZ9
• Q8NC46
• Q8TB23
• Q9H6S9
• Int3

Gene Name

• INTS3

Ensembl ID

• ENST00000318967
• ENSP00000318641
• ENSG00000143624
• ENST00000435409
• ENSP00000404290
• ENST00000512605
• ENSP00000425437
• ENST00000571768
• ENSP00000458631
• ENSG00000262826
• ENST00000576030
• ENSP00000460221
• ENST00000576422
• ENSP00000459907

Symbol

• C1orf193
• C1orf60
• INT3
• SOSSA
• SOSS-A
• C1orf60
• C1orf193

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
transcription factor binding site profile	0.77
disease perturbation	0.74
histone modification site profile	0.73
transcription factor	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.65   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 82   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.65   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0