Tclin ANO1 Anoctamin-1

Protein Summary

Description

Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.

Uniprot Accession IDs

• Q5XXA6
• A8KAM3
• Q8IYY8
• Q8N7V3

Gene Name

• ANO1

Ensembl ID

• ENST00000316296
• ENSP00000319477
• ENSG00000131620
• ENST00000355303
• ENSP00000347454
• ENST00000530676
• ENSP00000435797

Symbol

• DOG1
• ORAOV2
• TAOS2
• TMEM16A
• DOG1
• TAOS2
• ORAOV2
• TMEM16A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88
gene perturbation	0.87
cellular component	0.8
biological term	0.78
kinase perturbation	0.71

Protein Classes

DTO Classes

Protein / Ion Channel / Calcium-dependent Chloride Channel (Ca-clc) Family / Anoctamin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1000.12   (req: < 5)

Gene RIFs: 211   (req: <= 3)

Antibodies: 1224   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1000.12   (req: >= 5)

Gene RIFs: 211   (req: > 3)

Antibodies: 1224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 67

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1