USPL1
SUMO-specific isopeptidase USPL1
Protein Summary
SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172).
- ENST00000255304
- ENSP00000255304
- ENSG00000132952
- ENST00000614860
- ENSP00000480656
- C13orf22
- D13S106
- C13orf22
- D13S106E
- bA121O19.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.99 | ||
histone modification site profile | 0.88 | ||
disease perturbation | 0.83 | ||
transcription factor perturbation | 0.61 | ||
cell type or tissue | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.69 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 18 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.69 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 18 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0