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  5. Synaptophysin-like protein 2

Tbio Synaptophysin-like protein 2

Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.

 Comments

Property Summary

NCBI Gene PubMed Count 10
PubMed Score 23.11
PubTator Score 7.33

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
psoriasis 6685 4.88677129689478E-49
group 3 medulloblastoma 2254 9.12546709602406E-4
subependymal giant cell astrocytoma 2287 0.0300670338090859
Disease Target Count Z-score Confidence
Kidney disease 397 0.0 2.0
Disease Target Count Z-score Confidence
Central core myopathy 7 3.373 1.7

Expression

  Differential Expression (3)

Disease log2 FC p
group 3 medulloblastoma -1.500 0.001
subependymal giant cell astrocytoma 1.021 0.030
psoriasis -2.700 0.000

Synonym

Accession Q5VXT5 A8K0E8 A8KAL7 I0IT67 Q6ZMX1
Symbols MG29

Gene

SYPL2

PANTHER Protein Class (2)

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Mouse OMA Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG
Cow OMA EggNOG
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

 GO Function (1)

 GO Component (1)

 GO Process (2)

 Compartment GO Term (50)

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 MGI Term (2)

 GWAS Trait (1)

 HCA RNA Cell Line (51)

See all...

Pathway (1)

 UniProt Keyword (7)

Gene RIF (2)

PMID Text
25406998 SYPL2 is a susceptibility gene for morbid obesity.
22290180 Mitsugumin (MG)29 is expressed in astrocytes of Alzheimer disease brains associated with senile plaques, but is is not expressed in neurons around lesions.

AA Sequence 

MSSTESAGRTADKSPRQQVDRLLVGLRWRRLEEPLGFIKVLQWLFAIFAFGSCGSYSGETGAMVRCNNEA      1 - 70
KDVSSIIVAFGYPFRLHRIQYEMPLCDEESSSKTMHLMGDFSAPAEFFVTLGIFSFFYTMAALVIYLRFH     71 - 140
NLYTENKRFPLVDFCVTVSFTFFWLVAAAAWGKGLTDVKGATRPSSLTAAMSVCHGEEAVCSAGATPSMG    141 - 210
LANISVLFGFINFFLWAGNCWFVFKETPWHGQGQGQDQDQDQDQGQGPSQESAAEQGAVEKQ            211 - 272
//

Text Mined References (10)

PMID Year Title
25406998 2015 Exome sequencing followed by genotyping suggests SYPL2 as a susceptibility gene for morbid obesity.
22926577 2012 Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis.
22290180 2012 Mitsugumin 29 is transcriptionally induced in senile plaque-associated astrocytes.
20383146 2010 New loci associated with kidney function and chronic kidney disease.
20125088 2011 Genome-wide association study of recurrent early-onset major depressive disorder.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12975309 2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.