Tbio TTC39B Tetratricopeptide repeat protein 39B

Protein Summary

Description

Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3).

Uniprot Accession IDs

• Q5VTQ0
• A5PLN1
• B4DQ10
• B4DQX4
• B4DW93
• Q8IVR7
• Q8IXZ6
• Q8N267
• TPR repeat protein 39B

Gene Name

• TTC39B

Ensembl ID

• ENST00000297615
• ENSP00000297615
• ENSG00000155158
• ENST00000380850
• ENSP00000370231
• ENST00000507285
• ENSP00000426539
• ENST00000507993
• ENSP00000423392
• ENST00000512701
• ENSP00000422496

Symbol

• C9orf52
• C9orf52

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.95
transcription factor binding site profile	0.76
trait	0.75
transcription factor perturbation	0.74
histone modification site profile	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.68   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 93   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.68   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0