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Tdark
ATF7IP2
Activating transcription factor 7-interacting protein 2

Protein Summary
Description
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324570
  • ENSP00000322811
  • ENSG00000166669
  • ENST00000356427
  • ENSP00000348799
  • ENST00000396559
  • ENSP00000379807
  • ENST00000396560
  • ENSP00000379808

Symbol
  • MCAF2
  • MCAF2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.72
transcription factor
0.7
gene perturbation
0.56
microRNA
0.51
tissue sample
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.44   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.44   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0