Tchem AGBL2 Cytosolic carboxypeptidase 2

Protein Summary

Description

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.

Uniprot Accession IDs

• Q5U5Z8
• A8MPX2
• Q53FV5
• Q8IV57
• Q9H5C0

Gene Name

• AGBL2

Ensembl ID

• ENST00000525123
• ENSP00000435582
• ENSG00000165923
• ENST00000645431
• ENSP00000494229
• ENSG00000285501

Symbol

• CCP2
• CCP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.85
tissue sample	0.6
cell type or tissue	0.58
cell line	0.56
molecular function	0.56

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Cytosolic Carboxypeptidase 2

Protein / ... / Metalloprotease / Cytosolic Carboxypeptidase 2

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Cytosolic Carboxypeptidase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.98   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 105   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.98   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0