Property Summary

NCBI Gene PubMed Count 24
PubMed Score 16.47
PubTator Score 21.44

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
psoriasis 6685
Disease Target Count P-value
diabetes mellitus 1663 0.00122495309239543
Disease Target Count Z-score Confidence
Psoriatic arthritis 85 3.777 1.9

Gene RIF (26)

24566688 Our data suggest that The LCE deletion, previously identified in patients with psoriasis, is not of a major importance in the development of PsA in Tunisian patients
24485035 No evidence of association was seen between the LCE3C_LCE3B-del and psoriasis in 34 patients from 7 multiplex Tunisian families. No epistasic effect was found between the deletion and PSORS1 locus.
23631431 Our meta-analysis demonstrates a significant association between psoriasis and the LCE3C_LCE3B-del polymorphism in Europeans and Asians, but no association with psoriatic arthritis.
22926764 The LCE3C_LCE3B-del might play a role in familial psoriasis in the Tunisian population.
22512642 Paediatric-onset psoriasis is associated with .......... LCE3C_LCE3B deletion
22384135 LCE3C_LCE3B-del is a common risk factor for (auto)immune diseases
22048733 results suggest that the Koebner phenomenon in psoriasis is unlikely to be dependent on the LCE3B/C genotype
21995181 A deletion of LCE3B and LCE3C genes may promote the development of allergic contact dermatitis
21711330 The findings indicate that the LCE3C_LCE3B-del is an important risk factor in the pathogenesis of psoriasis and that the LCE3C_LCE3B-del does not show an epistatic effect with the HLA-Cw6 allele on susceptibility to psoriasis in the northern Chinese
21628307 This study provides evidence for an association between LCE3C_LCE3B-del and RA in non-Caucasian populations, and SNPs rs4112788 and rs4085613 tagging LCE3C_LCE3B-del were novel susceptibility factors for SLE.

AA Sequence

SNSCDRGSGQQDGASDCGYGSGGCC                                                  71 - 95

Text Mined References (24)

PMID Year Title
24566688 2014 Deletion of late cornified envelope genes, LCE3C_LCE3B-del, is not associated with psoriatic arthritis in Tunisian patients.
24485035 2014 Failure to find evidence for deletion of LCE3C and LCE3B genes at PSORS4 contributing to psoriasis susceptibility in Tunisian families.
23631431 2013 Association between the LCE3C_LCE3B deletion polymorphism and susceptibility to psoriasis: a meta-analysis of published studies.
22926764 2012 Association analysis of LCE3C-LCE3B deletion in Tunisian psoriatic population.
22512642 2012 Paediatric-onset psoriasis is associated with ERAP1 and IL23R loci, LCE3C_LCE3B deletion and HLA-C*06.
22384135 2012 A replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes LCE3B and LCE3C.
22048733 2012 Koebner phenomenon in psoriasis is not associated with deletion of late cornified envelope genes LCE3B and LCE3C.
21995181 2011 Deletion of the late cornified envelope genes LCE3B and LCE3C may promote chronic hand eczema with allergic contact dermatitis.
21711330 2011 Deletion of LCE3C and LCE3B genes is associated with psoriasis in a northern Chinese population.
21628307 2011 Deletion of LCE3C_LCE3B is associated with rheumatoid arthritis and systemic lupus erythematosus in the Chinese Han population.