| Tdark | KN motif and ankyrin repeat domain-containing protein 4 |
May be involved in the control of cytoskeleton formation by regulating actin polymerization.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 3.3e-52 |
| non-small cell lung cancer | 2890 | 4.7e-09 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 2.5e-05 |
| ependymoma | 4679 | 9.7e-05 |
| breast carcinoma | 1638 | 1.2e-04 |
| primary pancreatic ductal adenocarcinoma | 1109 | 4.9e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 7.2e-04 |
| Atopic dermatitis | 952 | 4.1e-03 |
| active Crohn's disease | 922 | 4.2e-03 |
| pancreatic cancer | 2398 | 4.4e-03 |
| active ulcerative colitis | 764 | 6.4e-03 |
| ovarian cancer | 8520 | 8.9e-03 |
| invasive ductal carcinoma | 2951 | 1.2e-02 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.4e-02 |
| pediatric high grade glioma | 1064 | 2.9e-02 |
| fibroadenoma | 559 | 3.9e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Fuchs' endothelial dystrophy | 24 | 3.439 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | -1.896 | 4.2e-03 |
| active ulcerative colitis | -2.667 | 6.4e-03 |
| Atopic dermatitis | -1.200 | 4.1e-03 |
| breast carcinoma | -1.800 | 1.2e-04 |
| ependymoma | -1.400 | 9.7e-05 |
| fibroadenoma | -1.500 | 3.9e-02 |
| intraductal papillary-mucinous adenoma (... | -2.200 | 2.4e-02 |
| intraductal papillary-mucinous carcinoma... | -3.900 | 2.5e-05 |
| intraductal papillary-mucinous neoplasm ... | -3.700 | 7.2e-04 |
| invasive ductal carcinoma | 1.002 | 1.2e-02 |
| non-small cell lung cancer | -1.089 | 4.7e-09 |
| ovarian cancer | -1.100 | 8.9e-03 |
| pancreatic cancer | -1.400 | 4.4e-03 |
| pediatric high grade glioma | -1.200 | 2.9e-02 |
| primary pancreatic ductal adenocarcinoma | -1.737 | 4.9e-04 |
| psoriasis | -1.900 | 3.3e-52 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG |
MEKTDAKDQSSQGDEEKDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLP 1 - 70 RNFSLPDSGARPPAAPPLQNWSPVVPREASLGTQEQNQSPPLGNAPQASTSRSEVSYHRKALLAEATRQL 71 - 140 EAAEPEDAELTFGSGRPQLLRASSMPATLLHSRASEEPGLSLGPPAPPALPPLQGEGSVCDGTFEPAEGL 141 - 210 AGFHSSSPRASTRIPELVQEGAEPPEGVVKVPNHLPLPGPPFSFQNVLVVLEDKEDEHNAREAEVLFTPG 211 - 280 SPTPSPPPLPSPIPENELLLEEIELNISEIPPPPPVEVDMRSIGIRVTEESLGLARVDPGSISSLKQQVS 281 - 350 ALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQFHQENAKDTQGQTDVMVNTDPVH 351 - 420 GLLTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGNQSPAERVLLPQLSLPQGPEQVLTSS 421 - 490 VHSFLSTELRIEEAGTEQEGGPQGGTRGAGGFLWGSDRKTPPAGREETSSNLPGKEHPGRPPSSPTDATI 491 - 560 GQYVKKIQELLQEQWNCLEHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAHPPKEPPASSSS 561 - 630 PPVEISPSTSLKSIMKKKDYGFRAGGNGTKKNLQFVGVNGGYETTSSEETSGEDSTPEDLSDSEAEKKCD 631 - 700 GPDHKHVKDAHLTCEAGQGIPEGTCHAAQESGPGEEVPHSKAERYKPSEEFLNACRALSQHLPETGTTTD 701 - 770 QLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIV 771 - 840 KLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDRED 841 - 910 MVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIA 911 - 980 GLLRAHAEQGRSLGL 981 - 995 //
