Tdark | KN motif and ankyrin repeat domain-containing protein 4 |
May be involved in the control of cytoskeleton formation by regulating actin polymerization.
Comments
Disease | Target Count | P-value |
---|---|---|
psoriasis | 6685 | 3.34448196852658E-52 |
non-small cell lung cancer | 2798 | 4.72151291610384E-9 |
intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 2.53542942925923E-5 |
posterior fossa group B ependymoma | 1530 | 1.05961915038341E-4 |
breast carcinoma | 1614 | 1.16487314444744E-4 |
primary pancreatic ductal adenocarcinoma | 1271 | 4.85334954160665E-4 |
intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 7.20067938225022E-4 |
Atopic dermatitis | 944 | 0.00407599654947812 |
active Crohn's disease | 918 | 0.00417130170230557 |
pancreatic cancer | 2300 | 0.00444005437240045 |
invasive ductal carcinoma | 2950 | 0.00635609290890401 |
active ulcerative colitis | 477 | 0.00637606559067656 |
ovarian cancer | 8492 | 0.00889945475030112 |
intraductal papillary-mucinous adenoma (IPMA) | 2956 | 0.0237651766624305 |
pediatric high grade glioma | 2712 | 0.0288016823868078 |
fibroadenoma | 557 | 0.0392763818743188 |
Disease | log2 FC | p |
---|---|---|
posterior fossa group B ependymoma | -1.600 | 0.000 |
Atopic dermatitis | -1.200 | 0.004 |
primary pancreatic ductal adenocarcinoma | -1.737 | 0.000 |
non-small cell lung cancer | -1.089 | 0.000 |
intraductal papillary-mucinous adenoma (... | -2.200 | 0.024 |
intraductal papillary-mucinous carcinoma... | -3.900 | 0.000 |
intraductal papillary-mucinous neoplasm ... | -3.700 | 0.001 |
active Crohn's disease | -1.896 | 0.004 |
active ulcerative colitis | -2.667 | 0.006 |
breast carcinoma | -1.800 | 0.000 |
fibroadenoma | -1.500 | 0.039 |
pediatric high grade glioma | -1.200 | 0.029 |
invasive ductal carcinoma | -2.600 | 0.006 |
ovarian cancer | -1.100 | 0.009 |
pancreatic cancer | -1.400 | 0.004 |
psoriasis | -1.900 | 0.000 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Opossum | OMA EggNOG Inparanoid |
Chicken | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Xenopus | OMA EggNOG Inparanoid |
PMID | Text |
---|---|
25961457 | identified recessive mutations in kidney ankyrin repeat-containing protein 1 (KANK1), KANK2, and KANK4 in individuals with nephrotic syndrome. |
MEKTDAKDQSSQGDEEKDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLP 1 - 70 RNFSLPDSGARPPAAPPLQNWSPVVPREASLGTQEQNQSPPLGNAPQASTSRSEVSYHRKALLAEATRQL 71 - 140 EAAEPEDAELTFGSGRPQLLRASSMPATLLHSRASEEPGLSLGPPAPPALPPLQGEGSVCDGTFEPAEGL 141 - 210 AGFHSSSPRASTRIPELVQEGAEPPEGVVKVPNHLPLPGPPFSFQNVLVVLEDKEDEHNAREAEVLFTPG 211 - 280 SPTPSPPPLPSPIPENELLLEEIELNISEIPPPPPVEVDMRSIGIRVTEESLGLARVDPGSISSLKQQVS 281 - 350 ALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQFHQENAKDTQGQTDVMVNTDPVH 351 - 420 GLLTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGNQSPAERVLLPQLSLPQGPEQVLTSS 421 - 490 VHSFLSTELRIEEAGTEQEGGPQGGTRGAGGFLWGSDRKTPPAGREETSSNLPGKEHPGRPPSSPTDATI 491 - 560 GQYVKKIQELLQEQWNCLEHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAHPPKEPPASSSS 561 - 630 PPVEISPSTSLKSIMKKKDYGFRAGGNGTKKNLQFVGVNGGYETTSSEETSGEDSTPEDLSDSEAEKKCD 631 - 700 GPDHKHVKDAHLTCEAGQGIPEGTCHAAQESGPGEEVPHSKAERYKPSEEFLNACRALSQHLPETGTTTD 701 - 770 QLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIV 771 - 840 KLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDRED 841 - 910 MVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIA 911 - 980 GLLRAHAEQGRSLGL 981 - 995 //
PMID | Year | Title |
---|---|---|
25961457 | 2015 | KANK deficiency leads to podocyte dysfunction and nephrotic syndrome. |
19554261 | 2009 | Kank proteins: structure, functions and diseases. |
17996375 | 2008 | Kank proteins: a new family of ankyrin-repeat domain-containing proteins. |
17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
16710414 | 2006 | The DNA sequence and biological annotation of human chromosome 1. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |