| Tdark | KN motif and ankyrin repeat domain-containing protein 4 |
May be involved in the control of cytoskeleton formation by regulating actin polymerization.
Comments
| Disease | log2 FC | p |
|---|---|---|
| posterior fossa group B ependymoma | -1.600 | 0.000 |
| Atopic dermatitis | -1.200 | 0.004 |
| primary pancreatic ductal adenocarcinoma | -1.737 | 0.000 |
| non-small cell lung cancer | -1.089 | 0.000 |
| intraductal papillary-mucinous adenoma (... | -2.200 | 0.024 |
| intraductal papillary-mucinous carcinoma... | -3.900 | 0.000 |
| intraductal papillary-mucinous neoplasm ... | -3.700 | 0.001 |
| active Crohn's disease | -1.896 | 0.004 |
| active ulcerative colitis | -2.667 | 0.006 |
| breast carcinoma | -1.800 | 0.000 |
| fibroadenoma | -1.500 | 0.039 |
| pediatric high grade glioma | -1.200 | 0.029 |
| invasive ductal carcinoma | -2.600 | 0.006 |
| ovarian cancer | -1.100 | 0.009 |
| pancreatic cancer | -1.400 | 0.004 |
| psoriasis | -1.900 | 0.000 |
| PMID | Text |
|---|---|
| 25961457 | identified recessive mutations in kidney ankyrin repeat-containing protein 1 (KANK1), KANK2, and KANK4 in individuals with nephrotic syndrome. |
MEKTDAKDQSSQGDEEKDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLP 1 - 70 RNFSLPDSGARPPAAPPLQNWSPVVPREASLGTQEQNQSPPLGNAPQASTSRSEVSYHRKALLAEATRQL 71 - 140 EAAEPEDAELTFGSGRPQLLRASSMPATLLHSRASEEPGLSLGPPAPPALPPLQGEGSVCDGTFEPAEGL 141 - 210 AGFHSSSPRASTRIPELVQEGAEPPEGVVKVPNHLPLPGPPFSFQNVLVVLEDKEDEHNAREAEVLFTPG 211 - 280 SPTPSPPPLPSPIPENELLLEEIELNISEIPPPPPVEVDMRSIGIRVTEESLGLARVDPGSISSLKQQVS 281 - 350 ALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQFHQENAKDTQGQTDVMVNTDPVH 351 - 420 GLLTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGNQSPAERVLLPQLSLPQGPEQVLTSS 421 - 490 VHSFLSTELRIEEAGTEQEGGPQGGTRGAGGFLWGSDRKTPPAGREETSSNLPGKEHPGRPPSSPTDATI 491 - 560 GQYVKKIQELLQEQWNCLEHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAHPPKEPPASSSS 561 - 630 PPVEISPSTSLKSIMKKKDYGFRAGGNGTKKNLQFVGVNGGYETTSSEETSGEDSTPEDLSDSEAEKKCD 631 - 700 GPDHKHVKDAHLTCEAGQGIPEGTCHAAQESGPGEEVPHSKAERYKPSEEFLNACRALSQHLPETGTTTD 701 - 770 QLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIV 771 - 840 KLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDRED 841 - 910 MVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIA 911 - 980 GLLRAHAEQGRSLGL 981 - 995 //
| PMID | Year | Title |
|---|---|---|
| 25961457 | 2015 | KANK deficiency leads to podocyte dysfunction and nephrotic syndrome. |
| 19554261 | 2009 | Kank proteins: structure, functions and diseases. |
| 17996375 | 2008 | Kank proteins: a new family of ankyrin-repeat domain-containing proteins. |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
| 16710414 | 2006 | The DNA sequence and biological annotation of human chromosome 1. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
