Tbio | DDB1- and CUL4-associated factor 12 |
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 2009]
This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 2009]
Comments
Disease | Target Count | P-value |
---|---|---|
hepatocellular carcinoma | 550 | 5.75378444033572E-6 |
tuberculosis and treatment for 6 months | 686 | 6.18348463684234E-4 |
pancreatic cancer | 2300 | 8.68915715376427E-4 |
pancreatic carcinoma | 567 | 8.68915715376427E-4 |
ovarian cancer | 8492 | 0.00112576400182733 |
ependymoma | 2514 | 0.0102349186959721 |
osteosarcoma | 7933 | 0.0115378540958672 |
acute myeloid leukemia | 785 | 0.0255825710228728 |
Disease | log2 FC | p |
---|---|---|
hepatocellular carcinoma | 1.400 | 0.000 |
pancreatic cancer | 1.400 | 0.001 |
ependymoma | 1.600 | 0.010 |
osteosarcoma | -1.638 | 0.012 |
tuberculosis and treatment for 6 months | -1.600 | 0.001 |
pancreatic carcinoma | 1.400 | 0.001 |
acute myeloid leukemia | -2.100 | 0.026 |
ovarian cancer | 1.700 | 0.001 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Dog | OMA Inparanoid |
Horse | OMA Inparanoid |
Cow | OMA Inparanoid |
Opossum | OMA Inparanoid |
Chicken | OMA Inparanoid |
Anole lizard | OMA Inparanoid |
MARKVVSRKRKAPASPGAGSDAQGPQFGWDHSLHKRKRLPPVKRSLVYYLKNREVRLQNETSYSRVLHGY 1 - 70 AAQQLPSLLKEREFHLGTLNKVFASQWLNHRQVVCGTKCNTLFVVDVQTSQITKIPILKDREPGGVTQQG 71 - 140 CGIHAIELNPSRTLLATGGDNPNSLAIYRLPTLDPVCVGDDGHKDWIFSIAWISDTMAVSGSRDGSMGLW 141 - 210 EVTDDVLTKSDARHNVSRVPVYAHITHKALKDIPKEDTNPDNCKVRALAFNNKNKELGAVSLDGYFHLWK 211 - 280 AENTLSKLLSTKLPYCRENVCLAYGSEWSVYAVGSQAHVSFLDPRQPSYNVKSVCSRERGSGIRSVSFYE 281 - 350 HIITVGTGQGSLLFYDIRAQRFLEERLSACYGSKPRLAGENLKLTTGKGWLNHDETWRNYFSDIDFFPNA 351 - 420 VYTHCYDSSGTKLFVAGGPLPSGLHGNYAGLWS 421 - 453 //
PMID | Year | Title |
---|---|---|
23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
19343178 | 2009 | Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. |
19295130 | 2009 | An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. |
18957058 | 2008 | Novel centrosome protein, TCC52, is a cancer-testis antigen. |
18096478 | 2007 | Gene expression profiling distinguishes a molecular signature for grade 1B mild acute cellular rejection in cardiac allograft recipients. |
17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
16964240 | 2006 | Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. |
16949367 | 2006 | A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. |
16341674 | 2005 | Transcriptome analysis of human gastric cancer. |
15761153 | 2005 | High-throughput mapping of a dynamic signaling network in mammalian cells. |
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