| Tbio | DDB1- and CUL4-associated factor 12 |
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 2009]
This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 2009]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| hepatocellular carcinoma | 547 | 5.8e-06 |
| ovarian cancer | 8520 | 2.3e-04 |
| tuberculosis and treatment for 6 months | 409 | 6.2e-04 |
| pancreatic cancer | 2398 | 8.7e-04 |
| pancreatic carcinoma | 562 | 8.7e-04 |
| ependymoma | 4679 | 1.0e-02 |
| osteosarcoma | 7950 | 1.2e-02 |
| acute myeloid leukemia | 783 | 2.6e-02 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | -2.100 | 2.6e-02 |
| ependymoma | 1.600 | 1.0e-02 |
| hepatocellular carcinoma | 1.400 | 5.8e-06 |
| osteosarcoma | -1.638 | 1.2e-02 |
| ovarian cancer | -1.200 | 2.3e-04 |
| pancreatic cancer | 1.400 | 8.7e-04 |
| pancreatic carcinoma | 1.400 | 8.7e-04 |
| tuberculosis and treatment for 6 months | -1.600 | 6.2e-04 |
MARKVVSRKRKAPASPGAGSDAQGPQFGWDHSLHKRKRLPPVKRSLVYYLKNREVRLQNETSYSRVLHGY 1 - 70 AAQQLPSLLKEREFHLGTLNKVFASQWLNHRQVVCGTKCNTLFVVDVQTSQITKIPILKDREPGGVTQQG 71 - 140 CGIHAIELNPSRTLLATGGDNPNSLAIYRLPTLDPVCVGDDGHKDWIFSIAWISDTMAVSGSRDGSMGLW 141 - 210 EVTDDVLTKSDARHNVSRVPVYAHITHKALKDIPKEDTNPDNCKVRALAFNNKNKELGAVSLDGYFHLWK 211 - 280 AENTLSKLLSTKLPYCRENVCLAYGSEWSVYAVGSQAHVSFLDPRQPSYNVKSVCSRERGSGIRSVSFYE 281 - 350 HIITVGTGQGSLLFYDIRAQRFLEERLSACYGSKPRLAGENLKLTTGKGWLNHDETWRNYFSDIDFFPNA 351 - 420 VYTHCYDSSGTKLFVAGGPLPSGLHGNYAGLWS 421 - 453 //
