Tdark TMTC4 Transmembrane and TPR repeat-containing protein 4

Protein Summary

Description

This gene encodes a transmembrane protein that belongs to family of proteins containing an N-terminal transmembrane domain and a C-terminal tetratricopeptide repeat (TPR) domain. TPR domains mediate protein-protein interactions in various cellular processes, such as synaptic vesicle fusion, protein folding, and protein translocation. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, Apr 2017]

Uniprot Accession IDs

• Q5T4D3
• A6NLI7
• B7Z666
• Q5T4D4
• Q5T4D5
• Q5T4D6
• Q8WV63
• Q96SU8

Gene Name

• TMTC4

Ensembl ID

• ENST00000328767
• ENSP00000365409
• ENSG00000125247
• ENST00000342624
• ENSP00000343871
• ENST00000376234
• ENSP00000365408

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.85
transcription factor perturbation	0.84
kinase perturbation	0.76
cell line	0.64
transcription factor binding site profile	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.84   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 120   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.84   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0