| Tbio | RNA-binding protein 20 |
RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes involved in cardiac development. Regulates splicing of TTN (Titin).
This gene encodes a protein that binds RNA and regulates splicing. Mutations in this gene have been associated with familial dilated cardiomyopathy. [provided by RefSeq, Apr 2014]
This gene encodes a protein that binds RNA and regulates splicing. Mutations in this gene have been associated with familial dilated cardiomyopathy. [provided by RefSeq, Apr 2014]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cardiomyopathy, Dilated, 1DD | 1 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| LEFT VENTRICULAR NONCOMPACTION 10 | 40 |
| LEFT VENTRICULAR NONCOMPACTION 8 | 40 |
| Disease | Target Count | P-value |
|---|---|---|
| pancreatic cancer | 2398 | 1.2e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.2e-04 |
| ependymoma | 4679 | 8.4e-04 |
| nasopharyngeal carcinoma | 1058 | 5.7e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.9e-02 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.2e-02 |
| pediatric high grade glioma | 1064 | 3.0e-02 |
| chronic rhinosinusitis | 512 | 4.1e-02 |
| acute myeloid leukemia | 783 | 4.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Dilated cardiomyopathy | 56 | 5.386 | 2.7 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cardiomyopathy | 116 | 0.0 | 4.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Arrhythmogenic right ventricular cardiomyopathy | 30 | 3.909 | 2.0 |
| Left ventricular noncompaction | 26 | 3.63 | 1.8 |
| Disease | Target Count |
|---|---|
| Familial isolated dilated cardiomyopathy | 41 |
| dilated cardiomyopathy 1DD | 2 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | -1.500 | 4.4e-02 |
| atypical teratoid / rhabdoid tumor | 3.000 | 1.2e-04 |
| chronic rhinosinusitis | -1.069 | 4.1e-02 |
| ependymoma | 1.500 | 8.4e-04 |
| intraductal papillary-mucinous adenoma (... | -1.200 | 2.2e-02 |
| intraductal papillary-mucinous carcinoma... | -1.300 | 1.9e-02 |
| nasopharyngeal carcinoma | -1.100 | 5.7e-03 |
| pancreatic cancer | -1.500 | 1.2e-04 |
| pediatric high grade glioma | 1.100 | 3.0e-02 |
MVLAAAMSQDADPSGPEQPDRVACSVPGARASPAPSGPRGMQQPPPPPQPPPPPQAGLPQIIQNAAKLLD 1 - 70 KNPFSVSNPNPLLPSPASLQLAQLQAQLTLHRLKLAQTAVTNNTAAATVLNQVLSKVAMSQPLFNQLRHP 71 - 140 SVITGPHGHAGVPQHAAAIPSTRFPSNAIAFSPPSQTRGPGPSMNLPNQPPSAMVMHPFTGVMPQTPGQP 141 - 210 AVILGIGKTGPAPATAGFYEYGKASSGQTYGPETDGQPGFLPSSASTSGSVTYEGHYSHTGQDGQAAFSK 211 - 280 DFYGPNSQGSHVASGFPAEQAGGLKSEVGPLLQGTNSQWESPHGFSGQSKPDLTAGPMWPPPHNQPYELY 281 - 350 DPEEPTSDRTPPSFGGRLNNSKQGFIGAGRRAKEDQALLSVRPLQAHELNDFHGVAPLHLPHICSICDKK 351 - 420 VFDLKDWELHVKGKLHAQKCLVFSENAGIRCILGSAEGTLCASPNSTAVYNPAGNEDYASNLGTSYVPIP 421 - 490 ARSFTQSSPTFPLASVGTTFAQRKGAGRVVHICNLPEGSCTENDVINLGLPFGKVTNYILMKSTNQAFLE 491 - 560 MAYTEAAQAMVQYYQEKSAVINGEKLLIRMSKRYKELQLKKPGKAVAAIIQDIHSQRERDMFREADRYGP 561 - 630 ERPRSRSPVSRSLSPRSHTPSFTSCSSSHSPPGPSRADWGNGRDSWEHSPYARREEERDPAPWRDNGDDK 631 - 700 RDRMDPWAHDRKHHPRQLDKAELDERPEGGRPHREKYPRSGSPNLPHSVSSYKSREDGYYRKEPKAKWDK 701 - 770 YLKQQQDAPGRSRRKDEARLRESRHPHPDDSGKEDGLGPKVTRAPEGAKAKQNEKNKTKRTDRDQEGADD 771 - 840 RKENTMAENEAGKEEQEGMEESPQSVGRQEKEAEFSDPENTRTKKEQDWESESEAEGESWYPTNMEELVT 841 - 910 VDEVGEEEDFIVEPDIPELEEIVPIDQKDKICPETCLCVTTTLDLDLAQDFPKEGVKAVGNGAAEISLKS 911 - 980 PRELPSASTSCPSDMDVEMPGLNLDAERKPAESETGLSLEDSDCYEKEAKGVESSDVHPAPTVQQMSSPK 981 - 1050 PAEERARQPSPFVDDCKTRGTPEDGACEGSPLEEKASPPIETDLQNQACQEVLTPENSRYVEMKSLEVRS 1051 - 1120 PEYTEVELKQPLSLPSWEPEDVFSELSIPLGVEFVVPRTGFYCKLCGLFYTSEETAKMSHCRSAVHYRNL 1121 - 1190 QKYLSQLAEEGLKETEGADSPRPEDSGIVPRFERKKL 1191 - 1227 //
