Tbio TREML2 Trem-like transcript 2 protein

Protein Summary

Description

Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q5T2D2
• Q08AP8
• Q08AP9
• Q8IWY0
• Q9H8E9
• TLT-2

Gene Name

• TREML2

Ensembl ID

• ENST00000483722
• ENSP00000418767
• ENSG00000112195

Symbol

• C6orf76
• TLT2
• TLT2
• TLT-2
• C6orf76
• dJ238O23.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.68
protein domain	0.58
microRNA	0.55
cell line	0.5
transcription factor	0.47

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.88   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.88   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0