1. Home
  2. Targets
  3. membrane traffic protein
  4. SNARE protein
  5. Synaptosomal-associated protein 47

Tdark Synaptosomal-associated protein 47

Plays a role in intracellular membrane fusion.

 Comments

Property Summary

NCBI Gene PubMed Count 8
PubMed Score 14.62
PubTator Score 9.75

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
ovarian cancer 8492 2.5261405778952E-7
atypical teratoid / rhabdoid tumor 4369 1.14128349099207E-5
glioblastoma 5572 1.18387767315301E-4
medulloblastoma, large-cell 6234 1.31897581666992E-4

Expression

  Differential Expression (4)

Disease log2 FC p
atypical teratoid / rhabdoid tumor -1.100 0.000
glioblastoma -1.200 0.000
medulloblastoma, large-cell -1.100 0.000
ovarian cancer 1.100 0.000

Synonym

Accession Q5SQN1 B6EDE0 Q5HYB5 Q5TBZ3 Q8N558 Q8TB31 Q8TCW8 Q8WV46 Q96CQ3 Q96FE1 Q96I66 Q96NU3 Q9BT10 Q9BVB2 SNAP-47
Symbols SVAP1
HEL170
SNAP-47
C1orf142
ESFI5812
HEL-S-290

Gene

SNAP47

PANTHER Protein Class (2)

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

 GO Function (2)

 GO Component (7)

 GO Process (3)

 Compartment GO Term (18)

See all...

 IMPC Term (3)

 MGI Term (3)

 HCA RNA Cell Line (56)

See all...

 UniProt Keyword (8)

Gene RIF (1)

PMID Text
22373659 Three proteins are identified: PAI-RBP1, C1orf142, and COTL1, which are differentially expressed in non-small cell lung cancer cell lines with different metastatic potential.

AA Sequence 

MRAARRGLHCAGAERPRRRGRLWDSSGVPQRQKRPGPWRTQTQEQMSRDVCIHTWPCTYYLEPKRRWVTG      1 - 70
QLSLTSLSLRFMTDSTGEILVSFPLSSIVEIKKEASHFIFSSITILEKGHAKHWFSSLRPSRNVVFSIIE     71 - 140
HFWRELLLSQPGAVADASVPRTRGEELTGLMAGSQKRLEDTARVLHHQGQQLDSVMRGLDKMESDLEVAD    141 - 210
RLLTELESPAWWPFSSKLWKTPPETKPREDVSMTSCEPFGKEGILIKIPAVISHRTESHVKPGRLTVLVS    211 - 280
GLEIHDSSSLLMHRFEREDVDDIKVHSPYEISIRQRFIGKPDMAYRLISAKMPEVIPILEVQFSKKMELL    281 - 350
EDALVLRSARTSSPAEKSCSVWHAASGLMGRTLHREPPAGDQEGTALHLQTSLPALSEADTQELTQILRR    351 - 420
MKGLALEAESELERQDEALDGVAAAVDRATLTIDKHNRRMKRLT                              421 - 464
//

Text Mined References (11)

PMID Year Title
26359495 2015 The Q-soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (Q-SNARE) SNAP-47 Regulates Trafficking of Selected Vesicle-associated Membrane Proteins (VAMPs).
25416956 2014 A proteome-scale map of the human interactome network.
22373659 2012 Differential expression of PAI-RBP1, C1orf142, and COTL1 in non-small cell lung cancer cell lines with different tumor metastatic potential.
19546860 2010 The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
16621800 2006 Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12975309 2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
More...