Tbio Q5R372 Rab GTPase-activating protein 1-like

Protein Summary

Description

GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity).

Uniprot Accession IDs

• Q5R372
• O75059
• Q3ZTR8
• Q5R369
• Q8IVV0
• Q8N921
• Q8WV78
• Q9NSP8
• Q9UQ19
• Q9UQP5
• Q9Y6Y5
• Q9Y6Y6

Gene Name

• RABGAP1L

Ensembl ID

• ENST00000251507
• ENSP00000251507
• ENSG00000152061
• ENST00000325589
• ENSP00000318603
• ENST00000347255
• ENSP00000281844
• ENST00000357444
• ENSP00000350027
• ENST00000367687
• ENSP00000356660
• ENST00000478442
• ENSP00000434600
• ENST00000486220
• ENSP00000432490
• ENST00000489615
• ENSP00000420660

Symbol

• HHL
• KIAA0471
• HHL
• TBC1D18

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
kinase perturbation	0.98
virus perturbation	0.94
PubMedID	0.9
transcription factor binding site profile	0.88

Protein Classes

PANTHER Classes

Protein / Hydrolase / Rab Gtpase-activating Protein 1-like

Protein / Enzyme Modulator / G-protein Modulator / Rab Gtpase-activating Protein 1-like

Protein / ... / Cysteine Protease / Rab Gtpase-activating Protein 1-like

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Rab Gtpase-activating Protein 1-like

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.77   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 68   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.77   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0