Tchem FFAR4 Free fatty acid receptor 4

Protein Summary

Description

Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation. This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q5NUL3
• Q495H1
• Q5VY25
• Q5VY26
• Q7Z605
• Q86SM7

Gene Name

• FFAR4

Ensembl ID

• ENST00000371481
• ENSP00000360536
• ENSG00000186188
• ENST00000371483
• ENSP00000360538

Symbol

• GPR120
• GPR129
• O3FAR1
• PGR4
• GT01
• PGR4
• BMIQ10
• GPR120
• GPR129
• O3FAR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.76
tissue	0.75
gene perturbation	0.71
molecular function	0.67
cell type or tissue	0.63

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Free Fatty Acid Receptor 4

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Free Fatty Acid Receptor / Free Fatty Acid Receptor 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 309.49   (req: < 5)

Gene RIFs: 77   (req: <= 3)

Antibodies: 329   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 309.49   (req: >= 5)

Gene RIFs: 77   (req: > 3)

Antibodies: 329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 83

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3