Protein Summary
The protein encoded by this gene belongs to the cytospin-A family. It is localized in the nucleus, and highly expressed in testis and some cancer cell lines. A chromosomal translocation involving this gene and platelet-derived growth factor receptor, beta gene (PDGFRB) may be a cause of juvenile myelomonocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
- ENST00000261503
- ENSP00000261503
- ENSG00000128487
- ENST00000395522
- ENSP00000378893
- ENST00000395525
- ENSP00000378896
- ENST00000395527
- ENSP00000378898
- ENST00000395529
- ENSP00000378900
- ENST00000395530
- ENSP00000378901
- CYTSB
- NSP5
- NSP
- CYTSB
- HCMOGT1
- HCMOGT-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
histone modification site profile | 0.88 | ||
transcription factor perturbation | 0.88 | ||
transcription factor binding site profile | 0.82 | ||
transcription factor | 0.74 | ||
virus perturbation | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 151.53 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 205 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 151.53 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 205 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0