Tdark WDR44 WD repeat-containing protein 44

Protein Summary

Description

Downstream effector for RAB11. May be involved in vesicle recycling (By similarity). This gene encodes a protein that interacts with the small GTPase rab11. A similar protein in rat binds the GTP-containing active form of rab11. This protein may play a role in endosome recycling. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Uniprot Accession IDs

• Q5JSH3
• B4DSE9
• F8W913
• Q0JS52
• Q0JTF3
• Q5JSH2
• Q6ZSC1
• Q7Z365
• Q7Z3P6
• Q8NAU8
• Q8NHU5
• Q9NUV4

Gene Name

• WDR44

Ensembl ID

• ENST00000254029
• ENSP00000254029
• ENSG00000131725
• ENST00000371822
• ENSP00000360887
• ENST00000371825
• ENSP00000360890

Symbol

• RPH11
• SYM-4
• RAB11BP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.96
tissue sample	0.62
cellular component	0.6
transcription factor binding site profile	0.59
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.79   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 29   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.79   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0