Protein Summary
Has antibacterial activity. This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
- ENST00000376314
- ENSP00000417128
- ENSG00000204548
- DEFB21
- DEFB21
- ESC42RELC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor | 0.36 | ||
biological term | 0.33 | ||
cell line | 0.33 | ||
tissue | 0.33 | ||
pathway | 0.32 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.52 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 67 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.52 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 67 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0