| Tbio | SH3 domain-containing protein 19 |
May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization.
This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Comments
| Disease | log2 FC | p |
|---|---|---|
| cystic fibrosis | 1.756 | 0.000 |
| atypical teratoid / rhabdoid tumor | 1.300 | 0.002 |
| glioblastoma | 1.200 | 0.003 |
| medulloblastoma, large-cell | 1.700 | 0.000 |
| juvenile dermatomyositis | 1.139 | 0.000 |
| adrenocortical carcinoma | -1.768 | 0.000 |
| primary pancreatic ductal adenocarcinoma | 1.417 | 0.001 |
| non-small cell lung cancer | -1.167 | 0.000 |
| breast carcinoma | -1.500 | 0.000 |
| fibroadenoma | -1.200 | 0.020 |
| lung adenocarcinoma | -1.700 | 0.000 |
| adult high grade glioma | 1.200 | 0.006 |
| group 4 medulloblastoma | 1.100 | 0.042 |
| pilocytic astrocytoma | 1.300 | 0.000 |
| lung carcinoma | -1.600 | 0.000 |
| spina bifida | -2.427 | 0.043 |
| Breast cancer | -1.400 | 0.000 |
| mucosa-associated lymphoid tissue lympho... | 1.086 | 0.016 |
| ductal carcinoma in situ | -1.600 | 0.001 |
| invasive ductal carcinoma | -2.400 | 0.000 |
| ovarian cancer | -2.100 | 0.000 |
| pituitary cancer | 1.300 | 0.000 |
| pancreatic cancer | 1.200 | 0.011 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG |
| Dog | OMA EggNOG Inparanoid |
| Horse | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Pig | OMA EggNOG Inparanoid |
| Opossum | OMA Inparanoid |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA Inparanoid |
| C. elegans | EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 17672918 | occurrence of an unusual TG 3' splice site in intron 6 |
| 15280379 | yeast two-hybrid screening using the cytoplasmic domain of ADAM12 as bait identified a protein designated Eve-1. Eve-1 plays a role in positively regulating the activity of ADAMs in the signaling of EGFR-ligand shedding. |
| 14551139 | identified and characterized EBP, a novel EEN binding protein that interacts with the SH3 domain of EEN; normally expressed in cytoplasm but recruited to the nucleus by MLL-EEN [EBP] |
MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPAANRASGEWDS 1 - 70 GTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIPGRGPLAESSDSGKKVPTPAP 71 - 140 RPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYKSLGEGPPANPPVPVLQSKPLVDIDLISFDD 141 - 210 DVLPTPSGNLAEESVGSEMVLDPFQLPAKTEPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLP 211 - 280 AEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPP 281 - 350 KLSATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHG 351 - 420 IANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQ 421 - 490 KPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 491 - 560 GKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVED 561 - 630 YPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCR 631 - 700 GRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSG 701 - 770 ELMGKSGIFPKNYIQFLQIS 771 - 790 //
| PMID | Year | Title |
|---|---|---|
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. |
| 21834987 | 2011 | Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. |
| 18669648 | 2008 | A quantitative atlas of mitotic phosphorylation. |
| 18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
| 17672918 | 2007 | Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. |
| 17116749 | 2006 | Comparative proteomics of clathrin-coated vesicles. |
| 16858696 | 2006 | Identification of novel Runx1 (AML1) translocation partner genes SH3D19, YTHDf2, and ZNF687 in acute myeloid leukemia. |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
| More... |
