| Tbio | SH3 domain-containing protein 19 |
May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization.
This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 1.3e-19 |
| lung adenocarcinoma | 2716 | 1.1e-16 |
| lung carcinoma | 2843 | 2.2e-15 |
| Breast cancer | 3578 | 8.0e-14 |
| juvenile dermatomyositis | 1187 | 1.0e-11 |
| ovarian cancer | 8520 | 1.1e-07 |
| Astrocytoma, Pilocytic | 3081 | 2.4e-06 |
| cystic fibrosis | 1696 | 5.2e-06 |
| medulloblastoma, large-cell | 6241 | 2.2e-05 |
| breast carcinoma | 1638 | 1.1e-04 |
| invasive ductal carcinoma | 2951 | 1.3e-04 |
| adrenocortical carcinoma | 1428 | 3.6e-04 |
| pituitary cancer | 1972 | 3.8e-04 |
| ductal carcinoma in situ | 1745 | 5.9e-04 |
| primary pancreatic ductal adenocarcinoma | 1109 | 1.3e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.0e-03 |
| glioblastoma | 5792 | 2.6e-03 |
| adult high grade glioma | 3801 | 6.4e-03 |
| pancreatic cancer | 2398 | 1.1e-02 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 1.6e-02 |
| fibroadenoma | 559 | 2.0e-02 |
| group 4 medulloblastoma | 1855 | 4.2e-02 |
| spina bifida | 1074 | 4.3e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | -1.768 | 3.6e-04 |
| adult high grade glioma | 1.200 | 6.4e-03 |
| Astrocytoma, Pilocytic | 1.300 | 2.4e-06 |
| atypical teratoid / rhabdoid tumor | 1.300 | 2.0e-03 |
| Breast cancer | -1.400 | 8.0e-14 |
| breast carcinoma | -1.500 | 1.1e-04 |
| cystic fibrosis | 1.756 | 5.2e-06 |
| ductal carcinoma in situ | -1.600 | 5.9e-04 |
| fibroadenoma | -1.200 | 2.0e-02 |
| glioblastoma | 1.200 | 2.6e-03 |
| group 4 medulloblastoma | 1.100 | 4.2e-02 |
| invasive ductal carcinoma | -2.400 | 1.3e-04 |
| juvenile dermatomyositis | 1.139 | 1.0e-11 |
| lung adenocarcinoma | -1.100 | 1.1e-16 |
| lung carcinoma | -1.600 | 2.2e-15 |
| medulloblastoma, large-cell | 1.700 | 2.2e-05 |
| mucosa-associated lymphoid tissue lympho... | 1.086 | 1.6e-02 |
| non-small cell lung cancer | -1.167 | 1.3e-19 |
| ovarian cancer | 1.400 | 1.1e-07 |
| pancreatic cancer | 1.200 | 1.1e-02 |
| pituitary cancer | 1.300 | 3.8e-04 |
| primary pancreatic ductal adenocarcinoma | 1.417 | 1.3e-03 |
| spina bifida | -2.427 | 4.3e-02 |
MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPAANRASGEWDS 1 - 70 GTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIPGRGPLAESSDSGKKVPTPAP 71 - 140 RPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYKSLGEGPPANPPVPVLQSKPLVDIDLISFDD 141 - 210 DVLPTPSGNLAEESVGSEMVLDPFQLPAKTEPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLP 211 - 280 AEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPP 281 - 350 KLSATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHG 351 - 420 IANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQ 421 - 490 KPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 491 - 560 GKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVED 561 - 630 YPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCR 631 - 700 GRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSG 701 - 770 ELMGKSGIFPKNYIQFLQIS 771 - 790 //
