PIGG
GPI ethanolamine phosphate transferase 2
Protein Summary
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose. This gene encodes an enzyme involved in glycosylphosphatidylinositol-anchor biosynthesis. The encoded protein, which is localized to the endoplasmic reticulum, is involved in transferring ethanoloamine phosphate to mannose 2 of glycosylphosphatidylinositol species H7 to form species H8. Allelic variants of this gene have been associated with intellectual disability, hypotonia, and early-onset seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
- ENST00000310340
- ENSP00000311750
- ENSG00000174227
- ENST00000383028
- ENSP00000372494
- ENST00000453061
- ENSP00000415203
- ENST00000503111
- ENSP00000426002
- GPI7
- GPI7
- LAS21
- MRT53
- PRO4405
- RLGS1930
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.86 | ||
transcription factor binding site profile | 0.8 | ||
metabolite | 0.73 | ||
tissue sample | 0.68 | ||
cellular component | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 76.07 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 9 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 76.07 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 9 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0