Tbio HERC4 Probable E3 ubiquitin-protein ligase HERC4

Protein Summary

Description

Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates. HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q5GLZ8
• Q5GC98
• Q5GC99
• Q5GCA0
• Q8IXP9
• Q9HCH9

Gene Name

• HERC4

Ensembl ID

• ENST00000277817
• ENSP00000277817
• ENSG00000148634
• ENST00000373700
• ENSP00000362804
• ENST00000395198
• ENSP00000378624
• ENST00000412272
• ENSP00000416504
• ENST00000473533
• ENSP00000423671
• ENST00000492996
• ENSP00000422383

Symbol

• KIAA1593

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
transcription factor perturbation	0.88
disease perturbation	0.74
transcription factor binding site profile	0.74
transcription factor	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.94   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 158   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.94   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0