| Tbio | von Willebrand factor A domain-containing protein 2 |
This gene encodes a member of the von Willebrand factor A-like domain protein superfamily. The encoded protein is localized to the extracellular matrix and may serve as a structural component in basement membranes or in anchoring structures on scaffolds of collagen VII or fibrillin. This gene has been linked to type 1A diabetes and is a candidate serological marker for colon cancer. [provided by RefSeq, Jan 2013]
Comments
Property Summary
| NCBI Gene PubMed Count | 13 |
| Grant Count | 19 |
| R01 Count | 4 |
| Funding | $2,152,386 |
| PubMed Score | 10.97 |
| PubTator Score | 7.33 |
| PMID | Text |
|---|---|
| 21385852 | We have revealed a novel Ca((2)+)-binding site at the A2 domain of VWF and demonstrated a relationship between Ca((2)+) and force in the regulation of VWF and primary hemostasis |
| 18492952 | By kinetic analysis of recombinant ADAMTS13 constructs, we show that the first thrombospondin-1, Cys-rich, and spacer domains of ADAMTS13 interact with segments of VWF domain A2 between Gln(1624) and Arg(1668). |
| 18434322 | O-glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO |
| 16385451 | Observational study of gene-disease association. (HuGE Navigator) |
| 15699509 | Single nucleotide polymorphisms in the AMACO gene are associated with dominant protection against Type 1A diabetes in an Arab family. |
| 15580307 | CCSP-2 is a novel candidate for development as a diagnostic serum marker of early stage colon cancer |
| 14506275 | AMACO is a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney |
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERS 1 - 70 KHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFSTQQEVKARIKRMVFKGGRTETELALKYLLHR 71 - 140 GLPGGRNASVPQILIIVTDGKSQGDVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQ 141 - 210 VEDATNGLFSTLSSSAICSSATPDCRVEAHPCEHRTLEMVREFAGNAPCWRGSRRTLAVLAAHCPFYSWK 211 - 280 RVFLTHPATCYRTTCPGPCDSQPCQNGGTCVPEGLDGYQCLCPLAFGGEANCALKLSLECRVDLLFLLDS 281 - 350 SAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQDVPDLVWSLDGIPFRGGPT 351 - 420 LTGSALRQAAERGFGSATRTGQDRPRRVVVLLTESHSEDEVAGPARHARARELLLLGVGSEAVRAELEEI 421 - 490 TGSPKHVMVYSDPQDLFNQIPELQGKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQ 491 - 560 FEVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARP 561 - 630 GVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVAAYADLRYHQDV 631 - 700 LIEWLCGEAKQPVNLCKPSPCMNEGSCVLQNGSYRCKCRDGWEGPHCENRFLRRP 701 - 755 //
| PMID | Year | Title |
|---|---|---|
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 22685543 | 2012 | A rapid cloning method employing orthogonal end protection. |
| 21385852 | 2011 | A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13. |
| 19199708 | 2009 | Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). |
| 18492952 | 2008 | Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity. |
| 18434322 | 2008 | O-glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO (VWA2 protein). |
| 16959974 | 2006 | The consensus coding sequences of human breast and colorectal cancers. |
| 16385451 | 2006 | A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
| 15699509 | 2004 | IDDM17: polymorphisms in the AMACO gene are associated with dominant protection against type 1A diabetes in a Bedouin Arab family. |
| More... |
